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Subcellular domain-restricted GABAergic innervation in primary visual cortex in the absence of sensory and thalamic inputs.

Publication ,  Journal Article
Di Cristo, G; Wu, C; Chattopadhyaya, B; Ango, F; Knott, G; Welker, E; Svoboda, K; Huang, ZJ
Published in: Nat Neurosci
November 2004

Distinct classes of GABAergic synapses target restricted subcellular domains, thereby differentially regulating the input, integration and output of principal neurons, but the underlying mechanism for such synapse segregation is unclear. Here we show that the distributions of two major classes of GABAergic synapses along the perisomatic and dendritic domains of pyramidal neurons were indistinguishable between primary visual cortex in vivo and cortical organotypic cultures. Therefore, subcellular synapse targeting is independent of thalamic input and probably involves molecular labels and experience-independent forms of activity.

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Published In

Nat Neurosci

DOI

ISSN

1097-6256

Publication Date

November 2004

Volume

7

Issue

11

Start / End Page

1184 / 1186

Location

United States

Related Subject Headings

  • gamma-Aminobutyric Acid
  • Visual Cortex
  • Thalamus
  • Synapses
  • Somatostatin
  • Pyramidal Cells
  • Parvalbumins
  • Organ Culture Techniques
  • Neurology & Neurosurgery
  • Models, Neurological
 

Citation

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Di Cristo, G., Wu, C., Chattopadhyaya, B., Ango, F., Knott, G., Welker, E., … Huang, Z. J. (2004). Subcellular domain-restricted GABAergic innervation in primary visual cortex in the absence of sensory and thalamic inputs. Nat Neurosci, 7(11), 1184–1186. https://doi.org/10.1038/nn1334
Di Cristo, Graziella, Caizhi Wu, Bidisha Chattopadhyaya, Fabrice Ango, Graham Knott, Egbert Welker, Karel Svoboda, and Z Josh Huang. “Subcellular domain-restricted GABAergic innervation in primary visual cortex in the absence of sensory and thalamic inputs.Nat Neurosci 7, no. 11 (November 2004): 1184–86. https://doi.org/10.1038/nn1334.
Di Cristo G, Wu C, Chattopadhyaya B, Ango F, Knott G, Welker E, et al. Subcellular domain-restricted GABAergic innervation in primary visual cortex in the absence of sensory and thalamic inputs. Nat Neurosci. 2004 Nov;7(11):1184–6.
Di Cristo, Graziella, et al. “Subcellular domain-restricted GABAergic innervation in primary visual cortex in the absence of sensory and thalamic inputs.Nat Neurosci, vol. 7, no. 11, Nov. 2004, pp. 1184–86. Pubmed, doi:10.1038/nn1334.
Di Cristo G, Wu C, Chattopadhyaya B, Ango F, Knott G, Welker E, Svoboda K, Huang ZJ. Subcellular domain-restricted GABAergic innervation in primary visual cortex in the absence of sensory and thalamic inputs. Nat Neurosci. 2004 Nov;7(11):1184–1186.

Published In

Nat Neurosci

DOI

ISSN

1097-6256

Publication Date

November 2004

Volume

7

Issue

11

Start / End Page

1184 / 1186

Location

United States

Related Subject Headings

  • gamma-Aminobutyric Acid
  • Visual Cortex
  • Thalamus
  • Synapses
  • Somatostatin
  • Pyramidal Cells
  • Parvalbumins
  • Organ Culture Techniques
  • Neurology & Neurosurgery
  • Models, Neurological