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Role of DNA methylation on the association between physical activity and cardiovascular diseases: results from the longitudinal multi-ethnic study of atherosclerosis (MESA) cohort.

Publication ,  Journal Article
Shi, H; Ossip, DJ; Mayo, NL; Lopez, DA; Block, RC; Post, WS; Bertoni, AG; Ding, J; Chen, S; Yan, C; Xie, Z; Hoeschele, I; Liu, Y; Li, D
Published in: BMC Genomics
November 3, 2021

BACKGROUND: The complexity of physical activity (PA) and DNA methylation interaction in the development of cardiovascular disease (CVD) is rarely simultaneously investigated in one study. We examined the role of DNA methylation on the association between PA and CVD. RESULTS: The Multi-Ethnic Study of Atherosclerosis (MESA) cohort Exam 5 data with 1065 participants free of CVD were used for final analysis. The quartile categorical total PA variable was created by activity intensity (METs/week). During a median follow-up of 4.0 years, 69 participants developed CVD. Illumina HumanMethylation450 BeadChip was used to provide genome-wide DNA methylation profiles in purified human monocytes (CD14+). We identified 23 candidate DNA methylation loci to be associated with both PA and CVD. We used the structural equation modeling (SEM) approach to test the complex relationships among multiple variables and the roles of mediators. Three of the 23 identified loci (corresponding to genes VPS13D, PIK3CD and VPS45) remained as significant mediators in the final SEM model along with other covariates. Bridged by the three genes, the 2nd PA quartile (β = - 0.959; 95%CI: - 1.554 to - 0.449) and the 3rd PA quartile (β = - 0.944; 95%CI: - 1.628 to - 0.413) showed the greatest inverse associations with CVD development, while the 4th PA quartile had a relatively weaker inverse association (β = - 0.355; 95%CI: - 0.713 to - 0.124). CONCLUSIONS: The current study is among the first to simultaneously examine the relationships among PA, DNA methylation, and CVD in a large cohort with long-term exposure. We identified three DNA methylation loci bridged the association between PA and CVD. The function of the identified genes warrants further investigation in the pathogenesis of CVD.

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Published In

BMC Genomics

DOI

EISSN

1471-2164

Publication Date

November 3, 2021

Volume

22

Issue

1

Start / End Page

790

Location

England

Related Subject Headings

  • Risk Factors
  • Humans
  • Exercise
  • Ethnicity
  • DNA Methylation
  • Cardiovascular Diseases
  • Bioinformatics
  • Atherosclerosis
  • 32 Biomedical and clinical sciences
  • 31 Biological sciences
 

Citation

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Shi, H., Ossip, D. J., Mayo, N. L., Lopez, D. A., Block, R. C., Post, W. S., … Li, D. (2021). Role of DNA methylation on the association between physical activity and cardiovascular diseases: results from the longitudinal multi-ethnic study of atherosclerosis (MESA) cohort. BMC Genomics, 22(1), 790. https://doi.org/10.1186/s12864-021-08108-w
Shi, Hangchuan, Deborah J. Ossip, Nicole L. Mayo, Daniel A. Lopez, Robert C. Block, Wendy S. Post, Alain G. Bertoni, et al. “Role of DNA methylation on the association between physical activity and cardiovascular diseases: results from the longitudinal multi-ethnic study of atherosclerosis (MESA) cohort.BMC Genomics 22, no. 1 (November 3, 2021): 790. https://doi.org/10.1186/s12864-021-08108-w.
Shi H, Ossip DJ, Mayo NL, Lopez DA, Block RC, Post WS, Bertoni AG, Ding J, Chen S, Yan C, Xie Z, Hoeschele I, Liu Y, Li D. Role of DNA methylation on the association between physical activity and cardiovascular diseases: results from the longitudinal multi-ethnic study of atherosclerosis (MESA) cohort. BMC Genomics. 2021 Nov 3;22(1):790.
Journal cover image

Published In

BMC Genomics

DOI

EISSN

1471-2164

Publication Date

November 3, 2021

Volume

22

Issue

1

Start / End Page

790

Location

England

Related Subject Headings

  • Risk Factors
  • Humans
  • Exercise
  • Ethnicity
  • DNA Methylation
  • Cardiovascular Diseases
  • Bioinformatics
  • Atherosclerosis
  • 32 Biomedical and clinical sciences
  • 31 Biological sciences