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High-strength, porous additively manufactured implants with optimized mechanical osseointegration.

Publication ,  Journal Article
Kelly, CN; Wang, T; Crowley, J; Wills, D; Pelletier, MH; Westrick, ER; Adams, SB; Gall, K; Walsh, WR
Published in: Biomaterials
December 2021

Optimization of porous titanium alloy scaffolds designed for orthopedic implants requires balancing mechanical properties and osseointegrative performance. The tradeoff between scaffold porosity and the stiffness/strength must be optimized towards the goal to improve long term load sharing while simultaneously promoting osseointegration. Osseointegration into porous titanium implants covering a wide range of porosity (0%-90%) and manufactured by laser powder bed fusion (LPBF) was evaluated with an established ovine cortical and cancellous defect model. Direct apposition and remodeling of woven bone was observed at the implant surface, as well as bone formation within the interstices of the pores. A linear relationship was observed between the porosity and benchtop mechanical properties of the scaffolds, while a non-linear relationship was observed between porosity and the ex vivo cortical bone-implant interfacial shear strength. Our study supports the hypothesis of porosity dependent performance tradeoffs, and establishes generalized relationships between porosity and performance for design of topological optimized implants for osseointegration. These results are widely applicable for orthopedic implant design for arthroplasty components, arthrodesis devices such as spinal interbody fusion implants, and patient matched implants for treatment of large bone defects.

Duke Scholars

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Published In

Biomaterials

DOI

EISSN

1878-5905

ISSN

0142-9612

Publication Date

December 2021

Volume

279

Start / End Page

121206

Related Subject Headings

  • Titanium
  • Sheep
  • Prostheses and Implants
  • Porosity
  • Osseointegration
  • Humans
  • Biomedical Engineering
  • Animals
  • Alloys
 

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Kelly, C. N., Wang, T., Crowley, J., Wills, D., Pelletier, M. H., Westrick, E. R., … Walsh, W. R. (2021). High-strength, porous additively manufactured implants with optimized mechanical osseointegration. Biomaterials, 279, 121206. https://doi.org/10.1016/j.biomaterials.2021.121206
Kelly, Cambre N., Tian Wang, James Crowley, Dan Wills, Matthew H. Pelletier, Edward R. Westrick, Samuel B. Adams, Ken Gall, and William R. Walsh. “High-strength, porous additively manufactured implants with optimized mechanical osseointegration.Biomaterials 279 (December 2021): 121206. https://doi.org/10.1016/j.biomaterials.2021.121206.
Kelly CN, Wang T, Crowley J, Wills D, Pelletier MH, Westrick ER, et al. High-strength, porous additively manufactured implants with optimized mechanical osseointegration. Biomaterials. 2021 Dec;279:121206.
Kelly, Cambre N., et al. “High-strength, porous additively manufactured implants with optimized mechanical osseointegration.Biomaterials, vol. 279, Dec. 2021, p. 121206. Epmc, doi:10.1016/j.biomaterials.2021.121206.
Kelly CN, Wang T, Crowley J, Wills D, Pelletier MH, Westrick ER, Adams SB, Gall K, Walsh WR. High-strength, porous additively manufactured implants with optimized mechanical osseointegration. Biomaterials. 2021 Dec;279:121206.
Journal cover image

Published In

Biomaterials

DOI

EISSN

1878-5905

ISSN

0142-9612

Publication Date

December 2021

Volume

279

Start / End Page

121206

Related Subject Headings

  • Titanium
  • Sheep
  • Prostheses and Implants
  • Porosity
  • Osseointegration
  • Humans
  • Biomedical Engineering
  • Animals
  • Alloys