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Optimizing the Impact of Pragmatic Clinical Trials for Veteran and Military Populations: Lessons From the Pain Management Collaboratory.

Publication ,  Journal Article
Ali, J; Antonelli, M; Bastian, L; Becker, W; Brandt, CA; Burgess, DJ; Burns, A; Cohen, SP; Davis, AF; Dearth, CL; Dziura, J; Edwards, R ...
Published in: Mil Med
July 1, 2022

Pragmatic clinical trials (PCTs) are well-suited to address unmet healthcare needs, such as those arising from the dual public health crises of chronic pain and opioid misuse, recently exacerbated by the COVID-19 pandemic. These overlapping epidemics have complex, multifactorial etiologies, and PCTs can be used to investigate the effectiveness of integrated therapies that are currently available but underused. Yet individual pragmatic studies can be limited in their reach because of existing structural and cultural barriers to dissemination and implementation. The National Institutes of Health, Department of Defense, and Department of Veterans Affairs formed an interagency research partnership, the Pain Management Collaboratory. The partnership combines pragmatic trial design with collaborative tools and relationship building within a large network to advance the science and impact of nonpharmacological approaches and integrated models of care for the management of pain and common co-occurring conditions. The Pain Management Collaboratory team supports 11 large-scale, multisite PCTs in veteran and military health systems with a focus on team science with the shared aim that the "whole is greater than the sum of the parts." Herein, we describe this integrated approach and lessons learned, including incentivizing all parties; proactively offering frequent opportunities for problem-solving; engaging stakeholders during all stages of research; and navigating competing research priorities. We also articulate several specific strategies and their practical implications for advancing pain management in active clinical, "real-world," settings.

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Published In

Mil Med

DOI

EISSN

1930-613X

Publication Date

July 1, 2022

Volume

187

Issue

7-8

Start / End Page

179 / 185

Location

England

Related Subject Headings

  • Veterans
  • Strategic, Defence & Security Studies
  • Research Design
  • Pragmatic Clinical Trials as Topic
  • Pandemics
  • Pain Management
  • Military Personnel
  • Humans
  • COVID-19
  • 4203 Health services and systems
 

Citation

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Ali, J., Antonelli, M., Bastian, L., Becker, W., Brandt, C. A., Burgess, D. J., … Zeliadt, S. (2022). Optimizing the Impact of Pragmatic Clinical Trials for Veteran and Military Populations: Lessons From the Pain Management Collaboratory. Mil Med, 187(7–8), 179–185. https://doi.org/10.1093/milmed/usab458
Ali, Joseph, Margaret Antonelli, Lori Bastian, William Becker, Cynthia A. Brandt, Diana J. Burgess, Amy Burns, et al. “Optimizing the Impact of Pragmatic Clinical Trials for Veteran and Military Populations: Lessons From the Pain Management Collaboratory.Mil Med 187, no. 7–8 (July 1, 2022): 179–85. https://doi.org/10.1093/milmed/usab458.
Ali J, Antonelli M, Bastian L, Becker W, Brandt CA, Burgess DJ, et al. Optimizing the Impact of Pragmatic Clinical Trials for Veteran and Military Populations: Lessons From the Pain Management Collaboratory. Mil Med. 2022 Jul 1;187(7–8):179–85.
Ali, Joseph, et al. “Optimizing the Impact of Pragmatic Clinical Trials for Veteran and Military Populations: Lessons From the Pain Management Collaboratory.Mil Med, vol. 187, no. 7–8, July 2022, pp. 179–85. Pubmed, doi:10.1093/milmed/usab458.
Ali J, Antonelli M, Bastian L, Becker W, Brandt CA, Burgess DJ, Burns A, Cohen SP, Davis AF, Dearth CL, Dziura J, Edwards R, Erdos J, Farrokhi S, Fritz J, Geda M, George SZ, Goertz C, Goodie J, Hastings SN, Heapy A, Ilfeld BM, Katsovich L, Kerns RD, Kyriakides TC, Lee A, Long CR, Luther SL, Martino S, Matheny ME, McGeary D, Midboe A, Pasquina P, Peduzzi P, Raffanello M, Rhon D, Rosen M, Esposito ER, Scarton D, Seal K, Silliker N, Taylor S, Taylor SL, Tsui M, Wright FS, Zeliadt S. Optimizing the Impact of Pragmatic Clinical Trials for Veteran and Military Populations: Lessons From the Pain Management Collaboratory. Mil Med. 2022 Jul 1;187(7–8):179–185.

Published In

Mil Med

DOI

EISSN

1930-613X

Publication Date

July 1, 2022

Volume

187

Issue

7-8

Start / End Page

179 / 185

Location

England

Related Subject Headings

  • Veterans
  • Strategic, Defence & Security Studies
  • Research Design
  • Pragmatic Clinical Trials as Topic
  • Pandemics
  • Pain Management
  • Military Personnel
  • Humans
  • COVID-19
  • 4203 Health services and systems