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Genetically encoded elastin-like polypeptide nanoparticles for drug delivery.

Publication ,  Journal Article
Milligan, JJ; Saha, S; Jenkins, IC; Chilkoti, A
Published in: Current opinion in biotechnology
April 2022

Small molecule drugs suffer from poor in vivo half-life, rapid degradation, and systemic off-target toxicity. To address these issues, researchers have developed nanoparticles that significantly enhance the delivery of many drugs while reducing their toxicity and improving targeting to specific organs. Recombinantly synthesized biomaterials such as elastin-like polypeptides (ELPs) have unique attributes that greatly facilitate the rational design of nanoparticles for drug delivery. These attributes include biocompatibility, precise control over amino acid sequence design, and stimuli-responsive self-assembly into nanostructures that can be loaded with a range of drugs to enhance their pharmacokinetics and pharmacodynamics, significantly improving their therapeutic efficacy over the free drugs. This review summarizes recent developments in genetically encoded, self-assembling ELP nanoparticles and their applications for drug delivery.

Duke Scholars

Published In

Current opinion in biotechnology

DOI

EISSN

1879-0429

ISSN

0958-1669

Publication Date

April 2022

Volume

74

Start / End Page

146 / 153

Related Subject Headings

  • Peptides
  • Nanoparticles
  • Elastin
  • Drug Delivery Systems
  • Biotechnology
  • Amino Acid Sequence
  • 3206 Medical biotechnology
  • 3106 Industrial biotechnology
  • 3001 Agricultural biotechnology
  • 10 Technology
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Milligan, J. J., Saha, S., Jenkins, I. C., & Chilkoti, A. (2022). Genetically encoded elastin-like polypeptide nanoparticles for drug delivery. Current Opinion in Biotechnology, 74, 146–153. https://doi.org/10.1016/j.copbio.2021.11.006
Milligan, Joshua J., Soumen Saha, Irene C. Jenkins, and Ashutosh Chilkoti. “Genetically encoded elastin-like polypeptide nanoparticles for drug delivery.Current Opinion in Biotechnology 74 (April 2022): 146–53. https://doi.org/10.1016/j.copbio.2021.11.006.
Milligan JJ, Saha S, Jenkins IC, Chilkoti A. Genetically encoded elastin-like polypeptide nanoparticles for drug delivery. Current opinion in biotechnology. 2022 Apr;74:146–53.
Milligan, Joshua J., et al. “Genetically encoded elastin-like polypeptide nanoparticles for drug delivery.Current Opinion in Biotechnology, vol. 74, Apr. 2022, pp. 146–53. Epmc, doi:10.1016/j.copbio.2021.11.006.
Milligan JJ, Saha S, Jenkins IC, Chilkoti A. Genetically encoded elastin-like polypeptide nanoparticles for drug delivery. Current opinion in biotechnology. 2022 Apr;74:146–153.
Journal cover image

Published In

Current opinion in biotechnology

DOI

EISSN

1879-0429

ISSN

0958-1669

Publication Date

April 2022

Volume

74

Start / End Page

146 / 153

Related Subject Headings

  • Peptides
  • Nanoparticles
  • Elastin
  • Drug Delivery Systems
  • Biotechnology
  • Amino Acid Sequence
  • 3206 Medical biotechnology
  • 3106 Industrial biotechnology
  • 3001 Agricultural biotechnology
  • 10 Technology