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Seroepidemiological survey on the impact of smoking on SARS-CoV-2 infection and COVID-19 outcomes: Protocol for the troina study

Publication ,  Journal Article
Polosa, R; Tomaselli, V; Ferrara, P; Romeo, AC; Rust, S; Saitta, D; Caraci, F; Romano, C; Thangaraju, M; Zuccarello, P; Rose, J; Cantone, GG ...
Published in: JMIR Research Protocols
November 1, 2021

Background: After the global spread of SARS-CoV-2, research has highlighted several aspects of the pandemic, focusing on clinical features and risk factors associated with infection and disease severity. However, emerging results on the role of smoking in SARS-CoV-2 infection susceptibility or COVID-19 outcomes are conflicting, and their robustness remains uncertain. Objective: In this context, this study aims at quantifying the proportion of SARS-CoV-2 antibody seroprevalence, studying the changes in antibody levels over time, and analyzing the association between the biochemically verified smoking status and SARS-CoV-2 infection. Methods: The research design involves a 6-month prospective cohort study with a serial sampling of the same individuals. Each participant will be surveyed about their demographics and COVID-19-related information, and blood sampling will be collected upon recruitment and at specified follow-up time points (ie, after 8 and 24 weeks). Blood samples will be screened for the presence of SARS-CoV-2-specific antibodies and serum cotinine, being the latter of the principal metabolite of nicotine, which will be used to assess participants' smoking status. Results: The study is ongoing. It aims to find a higher antibody prevalence in individuals at high risk for viral exposure (ie, health care personnel) and to refine current estimates on the association between smoking status and SARS-CoV-2/COVID-19. Conclusions: The added value of this research is that the current smoking status of the population to be studied will be biochemically verified to avoid the bias associated with self-reported smoking status. As such, the results from this survey may provide an actionable metric to study the role of smoking in SARS-CoV-2 infection and COVID-19 outcomes, and therefore to implement the most appropriate public health measures to control the pandemic. Results may also serve as a reference for future clinical research, and the methodology could be exploited in public health sectors and policies.

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Published In

JMIR Research Protocols

DOI

EISSN

1929-0748

Publication Date

November 1, 2021

Volume

10

Issue

11

Related Subject Headings

  • 1117 Public Health and Health Services
  • 1103 Clinical Sciences
 

Citation

APA
Chicago
ICMJE
MLA
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Polosa, R., Tomaselli, V., Ferrara, P., Romeo, A. C., Rust, S., Saitta, D., … Ferri, R. (2021). Seroepidemiological survey on the impact of smoking on SARS-CoV-2 infection and COVID-19 outcomes: Protocol for the troina study. JMIR Research Protocols, 10(11). https://doi.org/10.2196/32285
Polosa, R., V. Tomaselli, P. Ferrara, A. C. Romeo, S. Rust, D. Saitta, F. Caraci, et al. “Seroepidemiological survey on the impact of smoking on SARS-CoV-2 infection and COVID-19 outcomes: Protocol for the troina study.” JMIR Research Protocols 10, no. 11 (November 1, 2021). https://doi.org/10.2196/32285.
Polosa R, Tomaselli V, Ferrara P, Romeo AC, Rust S, Saitta D, et al. Seroepidemiological survey on the impact of smoking on SARS-CoV-2 infection and COVID-19 outcomes: Protocol for the troina study. JMIR Research Protocols. 2021 Nov 1;10(11).
Polosa, R., et al. “Seroepidemiological survey on the impact of smoking on SARS-CoV-2 infection and COVID-19 outcomes: Protocol for the troina study.” JMIR Research Protocols, vol. 10, no. 11, Nov. 2021. Scopus, doi:10.2196/32285.
Polosa R, Tomaselli V, Ferrara P, Romeo AC, Rust S, Saitta D, Caraci F, Romano C, Thangaraju M, Zuccarello P, Rose J, Cantone GG, Ferrante M, Belsey J, Cibella F, Interlandi E, Ferri R. Seroepidemiological survey on the impact of smoking on SARS-CoV-2 infection and COVID-19 outcomes: Protocol for the troina study. JMIR Research Protocols. 2021 Nov 1;10(11).

Published In

JMIR Research Protocols

DOI

EISSN

1929-0748

Publication Date

November 1, 2021

Volume

10

Issue

11

Related Subject Headings

  • 1117 Public Health and Health Services
  • 1103 Clinical Sciences