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High-grade neuroendocrine carcinomas of the lung highly express enhancer of zeste homolog 2, but carcinoids do not.

Publication ,  Journal Article
Findeis-Hosey, JJ; Huang, J; Li, F; Yang, Q; McMahon, LA; Xu, H
Published in: Hum Pathol
June 2011

Enhancer of zeste homolog 2, the catalytic subunit of polycomb repressive complex 2, is a histone methyltransferase and plays an important role in cell proliferation and cell cycle regulation. It has been shown to be overexpressed in a number of malignant neoplasms. This study aimed to determine the expression pattern of enhancer of zeste homolog 2 in neuroendocrine tumors of the lung and the potential of enhancer of zeste homolog 2 to serve as a biomarker to segregate carcinoids from high-grade neuroendocrine carcinomas. Fifty-four cases, including 25 typical carcinoids, 7 atypical carcinoids, 9 large-cell neuroendocrine carcinomas, and 13 small-cell lung carcinomas, were immunohistochemically studied using a monoclonal antibody against enhancer of zeste homolog 2. All 13 small-cell lung carcinomas demonstrated moderate to strong nuclear staining with 12 exhibiting more than 90% of tumor cells staining. All 9 large-cell neuroendocrine carcinomas were moderately to strongly positive for enhancer of zeste homolog 2, with 6 cases having staining in more than 80% of tumor cells. In contrast, all 25 typical carcinoids and 6 atypical carcinoids showed only rare scattered enhancer of zeste homolog 2-positive tumor cells, with 1 case of atypical carcinoid exhibiting moderate staining in 40% of tumor cells. A subsequent validation study of the 14 specimens of lung or mediastinal lymph node biopsy and fine-needle aspiration, including 6 small-cell lung carcinomas, 2 large-cell neuroendocrine carcinomas, 5 typical carcinoids, and 1 atypical carcinoid, was performed. Enhancer of zeste homolog 2 was diffusely and strongly positive in all small-cell lung carcinomas and large-cell neuroendocrine carcinomas, even with severe crush artifact, whereas it was only positive in rare tumor cells in carcinoids. These findings support the formulation that enhancer of zeste homolog 2 may play an important role in the regulation of biologic behavior of high-grade neuroendocrine carcinomas and as a diagnostically useful marker in distinguishing high-grade neuroendocrine carcinomas from carcinoids.

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Published In

Hum Pathol

DOI

EISSN

1532-8392

Publication Date

June 2011

Volume

42

Issue

6

Start / End Page

867 / 872

Location

United States

Related Subject Headings

  • Transcription Factors
  • Polycomb Repressive Complex 2
  • Pathology
  • Lung Neoplasms
  • Immunohistochemistry
  • Humans
  • Enhancer of Zeste Homolog 2 Protein
  • DNA-Binding Proteins
  • Carcinoma, Neuroendocrine
  • Carcinoid Tumor
 

Citation

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ICMJE
MLA
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Findeis-Hosey, J. J., Huang, J., Li, F., Yang, Q., McMahon, L. A., & Xu, H. (2011). High-grade neuroendocrine carcinomas of the lung highly express enhancer of zeste homolog 2, but carcinoids do not. Hum Pathol, 42(6), 867–872. https://doi.org/10.1016/j.humpath.2010.09.019
Findeis-Hosey, Jennifer J., Jiaoti Huang, Faqian Li, Qi Yang, Loralee A. McMahon, and Haodong Xu. “High-grade neuroendocrine carcinomas of the lung highly express enhancer of zeste homolog 2, but carcinoids do not.Hum Pathol 42, no. 6 (June 2011): 867–72. https://doi.org/10.1016/j.humpath.2010.09.019.
Findeis-Hosey JJ, Huang J, Li F, Yang Q, McMahon LA, Xu H. High-grade neuroendocrine carcinomas of the lung highly express enhancer of zeste homolog 2, but carcinoids do not. Hum Pathol. 2011 Jun;42(6):867–72.
Findeis-Hosey, Jennifer J., et al. “High-grade neuroendocrine carcinomas of the lung highly express enhancer of zeste homolog 2, but carcinoids do not.Hum Pathol, vol. 42, no. 6, June 2011, pp. 867–72. Pubmed, doi:10.1016/j.humpath.2010.09.019.
Findeis-Hosey JJ, Huang J, Li F, Yang Q, McMahon LA, Xu H. High-grade neuroendocrine carcinomas of the lung highly express enhancer of zeste homolog 2, but carcinoids do not. Hum Pathol. 2011 Jun;42(6):867–872.
Journal cover image

Published In

Hum Pathol

DOI

EISSN

1532-8392

Publication Date

June 2011

Volume

42

Issue

6

Start / End Page

867 / 872

Location

United States

Related Subject Headings

  • Transcription Factors
  • Polycomb Repressive Complex 2
  • Pathology
  • Lung Neoplasms
  • Immunohistochemistry
  • Humans
  • Enhancer of Zeste Homolog 2 Protein
  • DNA-Binding Proteins
  • Carcinoma, Neuroendocrine
  • Carcinoid Tumor