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Clonality of combined tumors.

Publication ,  Journal Article
Huang, J; Behrens, C; Wistuba, II; Gazdar, AF; Jagirdar, J
Published in: Arch Pathol Lab Med
April 2002

CONTEXT: Tumors with mixed morphologic patterns (combined tumors) are sometimes encountered, and questions often arise regarding the mechanism of molecular pathogenesis of each component and their relationships. OBJECTIVE: To determine whether different components of combined tumors contain the same or different genetic alterations, thus providing evidence for their clonality. MATERIALS AND METHODS: Six combined tumors with 2 components (in each case, both components showed epithelial differentiation morphologically) were studied by microdissecting tumor cells from each morphologic area followed by loss of heterozygosity analysis. RESULTS: In 1 of the cases studied, the different morphologic areas contained different patterns of genetic alterations. In the remaining 5 cases, the different morphologic areas harbored identical genetic changes in the chromosome regions studied. The latter group, interestingly, included a colonic tumor with an area of tubulovillous adenoma and an area of neuroendocrine carcinoma, and 2 lung tumors with squamous carcinoma and small cell carcinoma components. CONCLUSIONS: Our results suggest that in the majority of combined tumors, cells with different phenotypes share similar genotype and may arise from a single precursor cell. However, in a minority of these tumors, different areas may be derived from different precursor cells.

Duke Scholars

Published In

Arch Pathol Lab Med

DOI

ISSN

0003-9985

Publication Date

April 2002

Volume

126

Issue

4

Start / End Page

437 / 441

Location

United States

Related Subject Headings

  • Polymorphism, Restriction Fragment Length
  • Polymerase Chain Reaction
  • Pathology
  • Neoplasms, Multiple Primary
  • Mutation
  • Middle Aged
  • Microsatellite Repeats
  • Male
  • Lung Neoplasms
  • Loss of Heterozygosity
 

Citation

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MLA
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Huang, J., Behrens, C., Wistuba, I. I., Gazdar, A. F., & Jagirdar, J. (2002). Clonality of combined tumors. Arch Pathol Lab Med, 126(4), 437–441. https://doi.org/10.5858/2002-126-0437-COCT
Huang, Jiaoti, Carmen Behrens, Ignacio I. Wistuba, Adi F. Gazdar, and Jaishree Jagirdar. “Clonality of combined tumors.Arch Pathol Lab Med 126, no. 4 (April 2002): 437–41. https://doi.org/10.5858/2002-126-0437-COCT.
Huang J, Behrens C, Wistuba II, Gazdar AF, Jagirdar J. Clonality of combined tumors. Arch Pathol Lab Med. 2002 Apr;126(4):437–41.
Huang, Jiaoti, et al. “Clonality of combined tumors.Arch Pathol Lab Med, vol. 126, no. 4, Apr. 2002, pp. 437–41. Pubmed, doi:10.5858/2002-126-0437-COCT.
Huang J, Behrens C, Wistuba II, Gazdar AF, Jagirdar J. Clonality of combined tumors. Arch Pathol Lab Med. 2002 Apr;126(4):437–441.

Published In

Arch Pathol Lab Med

DOI

ISSN

0003-9985

Publication Date

April 2002

Volume

126

Issue

4

Start / End Page

437 / 441

Location

United States

Related Subject Headings

  • Polymorphism, Restriction Fragment Length
  • Polymerase Chain Reaction
  • Pathology
  • Neoplasms, Multiple Primary
  • Mutation
  • Middle Aged
  • Microsatellite Repeats
  • Male
  • Lung Neoplasms
  • Loss of Heterozygosity