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DunedinPACE, a DNA methylation biomarker of the pace of aging.

Publication ,  Journal Article
Belsky, DW; Caspi, A; Corcoran, DL; Sugden, K; Poulton, R; Arseneault, L; Baccarelli, A; Chamarti, K; Gao, X; Hannon, E; Harrington, HL ...
Published in: eLife
January 2022

Measures to quantify changes in the pace of biological aging in response to intervention are needed to evaluate geroprotective interventions for humans. Previously, we showed that quantification of the pace of biological aging from a DNA-methylation blood test was possible (Belsky et al., 2020). Here, we report a next-generation DNA-methylation biomarker of Pace of Aging, DunedinPACE (for Pace of Aging Calculated from the Epigenome).We used data from the Dunedin Study 1972-1973 birth cohort tracking within-individual decline in 19 indicators of organ-system integrity across four time points spanning two decades to model Pace of Aging. We distilled this two-decade Pace of Aging into a single-time-point DNA-methylation blood-test using elastic-net regression and a DNA-methylation dataset restricted to exclude probes with low test-retest reliability. We evaluated the resulting measure, named DunedinPACE, in five additional datasets.DunedinPACE showed high test-retest reliability, was associated with morbidity, disability, and mortality, and indicated faster aging in young adults with childhood adversity. DunedinPACE effect-sizes were similar to GrimAge Clock effect-sizes. In analysis of incident morbidity, disability, and mortality, DunedinPACE and added incremental prediction beyond GrimAge.DunedinPACE is a novel blood biomarker of the pace of aging for gerontology and geroscience.This research was supported by US-National Institute on Aging grants AG032282, AG061378, AG066887, and UK Medical Research Council grant MR/P005918/1.

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Published In

eLife

DOI

EISSN

2050-084X

ISSN

2050-084X

Publication Date

January 2022

Volume

11

Start / End Page

e73420

Related Subject Headings

  • New Zealand
  • Male
  • Humans
  • Female
  • Epigenome
  • Epigenesis, Genetic
  • DNA Methylation
  • Cohort Studies
  • Child, Preschool
  • Child
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Belsky, D. W., Caspi, A., Corcoran, D. L., Sugden, K., Poulton, R., Arseneault, L., … Moffitt, T. E. (2022). DunedinPACE, a DNA methylation biomarker of the pace of aging. ELife, 11, e73420. https://doi.org/10.7554/elife.73420
Belsky, Daniel W., Avshalom Caspi, David L. Corcoran, Karen Sugden, Richie Poulton, Louise Arseneault, Andrea Baccarelli, et al. “DunedinPACE, a DNA methylation biomarker of the pace of aging.ELife 11 (January 2022): e73420. https://doi.org/10.7554/elife.73420.
Belsky DW, Caspi A, Corcoran DL, Sugden K, Poulton R, Arseneault L, et al. DunedinPACE, a DNA methylation biomarker of the pace of aging. eLife. 2022 Jan;11:e73420.
Belsky, Daniel W., et al. “DunedinPACE, a DNA methylation biomarker of the pace of aging.ELife, vol. 11, Jan. 2022, p. e73420. Epmc, doi:10.7554/elife.73420.
Belsky DW, Caspi A, Corcoran DL, Sugden K, Poulton R, Arseneault L, Baccarelli A, Chamarti K, Gao X, Hannon E, Harrington HL, Houts R, Kothari M, Kwon D, Mill J, Schwartz J, Vokonas P, Wang C, Williams BS, Moffitt TE. DunedinPACE, a DNA methylation biomarker of the pace of aging. eLife. 2022 Jan;11:e73420.

Published In

eLife

DOI

EISSN

2050-084X

ISSN

2050-084X

Publication Date

January 2022

Volume

11

Start / End Page

e73420

Related Subject Headings

  • New Zealand
  • Male
  • Humans
  • Female
  • Epigenome
  • Epigenesis, Genetic
  • DNA Methylation
  • Cohort Studies
  • Child, Preschool
  • Child