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From high-throughput to therapeutic: host-directed interventions against influenza viruses.

Publication ,  Journal Article
Trimarco, JD; Heaton, NS
Published in: Curr Opin Virol
April 2022

Influenza viruses are simultaneously supported and antagonized by factors within the host cell. This close relationship is the theoretical basis for future antivirals that target the host rather than the virus itself, a concept termed host-directed therapeutics. Genetic screening has led to the identification of host factors capable of modulating influenza virus infections, and these factors represent candidate targets for host-directed antiviral strategies. Despite advances in understanding host targets, however, there are currently no host-directed interventions for influenza viruses in clinical use. In this brief review, we discuss some host factors identified in knockout/knockdown and overexpression screens that could potentially be targeted as host-directed influenza intervention strategies. We further comment on the feasibility of changing gene expression in the respiratory tract with RNA delivery vectors and transient CRISPR-mediated gene targeting.

Duke Scholars

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Published In

Curr Opin Virol

DOI

EISSN

1879-6265

Publication Date

April 2022

Volume

53

Start / End Page

101198

Location

Netherlands

Related Subject Headings

  • Orthomyxoviridae
  • Influenza, Human
  • Influenza A virus
  • Humans
  • Host-Pathogen Interactions
  • Antiviral Agents
  • 3107 Microbiology
  • 1108 Medical Microbiology
  • 0605 Microbiology
 

Citation

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Trimarco, J. D., & Heaton, N. S. (2022). From high-throughput to therapeutic: host-directed interventions against influenza viruses. Curr Opin Virol, 53, 101198. https://doi.org/10.1016/j.coviro.2021.12.014
Trimarco, Joseph D., and Nicholas S. Heaton. “From high-throughput to therapeutic: host-directed interventions against influenza viruses.Curr Opin Virol 53 (April 2022): 101198. https://doi.org/10.1016/j.coviro.2021.12.014.
Trimarco JD, Heaton NS. From high-throughput to therapeutic: host-directed interventions against influenza viruses. Curr Opin Virol. 2022 Apr;53:101198.
Trimarco, Joseph D., and Nicholas S. Heaton. “From high-throughput to therapeutic: host-directed interventions against influenza viruses.Curr Opin Virol, vol. 53, Apr. 2022, p. 101198. Pubmed, doi:10.1016/j.coviro.2021.12.014.
Trimarco JD, Heaton NS. From high-throughput to therapeutic: host-directed interventions against influenza viruses. Curr Opin Virol. 2022 Apr;53:101198.
Journal cover image

Published In

Curr Opin Virol

DOI

EISSN

1879-6265

Publication Date

April 2022

Volume

53

Start / End Page

101198

Location

Netherlands

Related Subject Headings

  • Orthomyxoviridae
  • Influenza, Human
  • Influenza A virus
  • Humans
  • Host-Pathogen Interactions
  • Antiviral Agents
  • 3107 Microbiology
  • 1108 Medical Microbiology
  • 0605 Microbiology