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Autoimmune encephalitis: proposed recommendations for symptomatic and long-term management.

Publication ,  Journal Article
Abboud, H; Probasco, J; Irani, SR; Ances, B; Benavides, DR; Bradshaw, M; Christo, PP; Dale, RC; Fernandez-Fournier, M; Flanagan, EP; Gadoth, A ...
Published in: J Neurol Neurosurg Psychiatry
March 1, 2021

The objective of this paper is to evaluate available evidence for each step in autoimmune encephalitis management and provide expert opinion when evidence is lacking. The paper approaches autoimmune encephalitis as a broad category rather than focusing on individual antibody syndromes. Core authors from the Autoimmune Encephalitis Alliance Clinicians Network reviewed literature and developed the first draft. Where evidence was lacking or controversial, an electronic survey was distributed to all members to solicit individual responses. Sixty-eight members from 17 countries answered the survey. The most popular bridging therapy was oral prednisone taper chosen by 38% of responders while rituximab was the most popular maintenance therapy chosen by 46%. Most responders considered maintenance immunosuppression after a second relapse in patients with neuronal surface antibodies (70%) or seronegative autoimmune encephalitis (61%) as opposed to those with onconeuronal antibodies (29%). Most responders opted to cancer screening for 4 years in patients with neuronal surface antibodies (49%) or limbic encephalitis (46%) as opposed to non-limbic seronegative autoimmune encephalitis (36%). Detailed survey results are presented in the manuscript and a summary of the diagnostic and therapeutic recommendations is presented at the conclusion.

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Published In

J Neurol Neurosurg Psychiatry

DOI

EISSN

1468-330X

Publication Date

March 1, 2021

Volume

92

Issue

8

Start / End Page

897 / 907

Location

England

Related Subject Headings

  • Neurology & Neurosurgery
  • 3209 Neurosciences
  • 3202 Clinical sciences
  • 17 Psychology and Cognitive Sciences
  • 11 Medical and Health Sciences
 

Citation

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Abboud, H., Probasco, J., Irani, S. R., Ances, B., Benavides, D. R., Bradshaw, M., … Autoimmune Encephalitis Alliance Clinicians Network. (2021). Autoimmune encephalitis: proposed recommendations for symptomatic and long-term management. J Neurol Neurosurg Psychiatry, 92(8), 897–907. https://doi.org/10.1136/jnnp-2020-325302
Abboud, Hesham, John Probasco, Sarosh R. Irani, Beau Ances, David R. Benavides, Michael Bradshaw, Paulo Pereira Christo, et al. “Autoimmune encephalitis: proposed recommendations for symptomatic and long-term management.J Neurol Neurosurg Psychiatry 92, no. 8 (March 1, 2021): 897–907. https://doi.org/10.1136/jnnp-2020-325302.
Abboud H, Probasco J, Irani SR, Ances B, Benavides DR, Bradshaw M, et al. Autoimmune encephalitis: proposed recommendations for symptomatic and long-term management. J Neurol Neurosurg Psychiatry. 2021 Mar 1;92(8):897–907.
Abboud, Hesham, et al. “Autoimmune encephalitis: proposed recommendations for symptomatic and long-term management.J Neurol Neurosurg Psychiatry, vol. 92, no. 8, Mar. 2021, pp. 897–907. Pubmed, doi:10.1136/jnnp-2020-325302.
Abboud H, Probasco J, Irani SR, Ances B, Benavides DR, Bradshaw M, Christo PP, Dale RC, Fernandez-Fournier M, Flanagan EP, Gadoth A, George P, Grebenciucova E, Jammoul A, Lee S-T, Li Y, Matiello M, Morse AM, Rae-Grant A, Rojas G, Rossman I, Schmitt S, Venkatesan A, Vernino S, Pittock SJ, Titulaer M, Autoimmune Encephalitis Alliance Clinicians Network. Autoimmune encephalitis: proposed recommendations for symptomatic and long-term management. J Neurol Neurosurg Psychiatry. 2021 Mar 1;92(8):897–907.

Published In

J Neurol Neurosurg Psychiatry

DOI

EISSN

1468-330X

Publication Date

March 1, 2021

Volume

92

Issue

8

Start / End Page

897 / 907

Location

England

Related Subject Headings

  • Neurology & Neurosurgery
  • 3209 Neurosciences
  • 3202 Clinical sciences
  • 17 Psychology and Cognitive Sciences
  • 11 Medical and Health Sciences