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Clinical Approach to Cardiovascular Toxicity of Oral Antineoplastic Agents: JACC State-of-the-Art Review.

Publication ,  Journal Article
Rao, VU; Reeves, DJ; Chugh, AR; O'Quinn, R; Fradley, MG; Raghavendra, M; Dent, S; Barac, A; Lenihan, D
Published in: J Am Coll Cardiol
June 1, 2021

Precision medicine has ushered in a new era of targeted treatments for numerous malignancies, leading to improvements in overall survival. Unlike traditional chemotherapy, many molecular targeted antineoplastic agents are available in oral formulation, leading to enhanced patient convenience and a perception of reduced risk of adverse effects. Although oral antineoplastic agents are generally well-tolerated, cardiovascular toxicities are being reported with increasing frequency in part due to U.S. Food and Drug Administration and manufacturer recommended cardiac monitoring. Monitoring strategies have focused on left ventricular dysfunction, hypertension, and QT prolongation/arrhythmias. Given the rapid pace of development and availability of new oral antineoplastic agents, the purpose of this review is to provide clinicians with an up-to-date practical approach to monitoring and management of cardiovascular toxicities with the aim of improving overall outcomes for patients with cancer.

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Published In

J Am Coll Cardiol

DOI

EISSN

1558-3597

Publication Date

June 1, 2021

Volume

77

Issue

21

Start / End Page

2693 / 2716

Location

United States

Related Subject Headings

  • Ventricular Dysfunction, Left
  • Risk Assessment
  • Protein-Tyrosine Kinases
  • Incidence
  • Hypertension
  • Humans
  • Drug Labeling
  • Cardiovascular System & Hematology
  • Cardiotoxicity
  • Arrhythmias, Cardiac
 

Citation

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Rao, V. U., Reeves, D. J., Chugh, A. R., O’Quinn, R., Fradley, M. G., Raghavendra, M., … Lenihan, D. (2021). Clinical Approach to Cardiovascular Toxicity of Oral Antineoplastic Agents: JACC State-of-the-Art Review. J Am Coll Cardiol, 77(21), 2693–2716. https://doi.org/10.1016/j.jacc.2021.04.009
Rao, Vijay U., David J. Reeves, Atul R. Chugh, Rupal O’Quinn, Michael G. Fradley, Meghana Raghavendra, Susan Dent, Ana Barac, and Daniel Lenihan. “Clinical Approach to Cardiovascular Toxicity of Oral Antineoplastic Agents: JACC State-of-the-Art Review.J Am Coll Cardiol 77, no. 21 (June 1, 2021): 2693–2716. https://doi.org/10.1016/j.jacc.2021.04.009.
Rao VU, Reeves DJ, Chugh AR, O’Quinn R, Fradley MG, Raghavendra M, et al. Clinical Approach to Cardiovascular Toxicity of Oral Antineoplastic Agents: JACC State-of-the-Art Review. J Am Coll Cardiol. 2021 Jun 1;77(21):2693–716.
Rao, Vijay U., et al. “Clinical Approach to Cardiovascular Toxicity of Oral Antineoplastic Agents: JACC State-of-the-Art Review.J Am Coll Cardiol, vol. 77, no. 21, June 2021, pp. 2693–716. Pubmed, doi:10.1016/j.jacc.2021.04.009.
Rao VU, Reeves DJ, Chugh AR, O’Quinn R, Fradley MG, Raghavendra M, Dent S, Barac A, Lenihan D. Clinical Approach to Cardiovascular Toxicity of Oral Antineoplastic Agents: JACC State-of-the-Art Review. J Am Coll Cardiol. 2021 Jun 1;77(21):2693–2716.
Journal cover image

Published In

J Am Coll Cardiol

DOI

EISSN

1558-3597

Publication Date

June 1, 2021

Volume

77

Issue

21

Start / End Page

2693 / 2716

Location

United States

Related Subject Headings

  • Ventricular Dysfunction, Left
  • Risk Assessment
  • Protein-Tyrosine Kinases
  • Incidence
  • Hypertension
  • Humans
  • Drug Labeling
  • Cardiovascular System & Hematology
  • Cardiotoxicity
  • Arrhythmias, Cardiac