Skip to main content
construction release_alert
Scholars@Duke will be undergoing maintenance April 11-15. Some features may be unavailable during this time.
cancel

Cardiac management during adjuvant trastuzumab therapy: Recommendations of the Canadian Trastuzumab Working Group

Publication ,  Journal Article
Mackey, JR; Clemons, M; Côté, MA; Delgado, D; Dent, S; Paterson, A; Provencher, L; Sawyer, MB; Verma, S
Published in: Current Oncology
January 1, 2008

Trastuzumab has been shown to be an effective therapy for women with breast cancer that overexpresses the human epidermal growth factor receptor 2 (HER2) protein. In the pivotal metastatic breast cancer trials, cardiac dysfunction was observed in women treated with trastuzumab and chemotherapy. The incidence and severity of cardiac dysfunction was greatest among patients who received trastuzumab in combination with anthracycline-based therapy. Those findings influenced the design of subsequent trastuzumab trials to include prospective evaluations of cardiac effects and protocols for cardiac monitoring and management. The risk of cardiotoxicity has also driven efforts to develop non-anthracycline-based regimens for women with HER2-positive breast cancers. With the increasing use of trastuzumab, particularly in the curative adjuvant setting, the need for a rational approach to the treatment and cardiac management of the relevant patient population is clear. The mandate of the Canadian Trastuzumab Working Group was to formulate recommendations, based on available data, for the assessment and management of cardiac complications during adjuvant trastuzumab therapy. The panel formulated recommendations in four areas: • Risk factors for cardiotoxicity. • Effects of various regimens. • Monitoring • Management The recommendations published here are expected to evolve as more data become available and experience with traztuzumab in the adjuvant setting grows. Copyright © 2008 Multimed Inc.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Current Oncology

DOI

EISSN

1718-7729

Publication Date

January 1, 2008

Volume

15

Issue

1

Start / End Page

24 / 35

Related Subject Headings

  • Oncology & Carcinogenesis
  • 3211 Oncology and carcinogenesis
  • 1112 Oncology and Carcinogenesis
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Mackey, J. R., Clemons, M., Côté, M. A., Delgado, D., Dent, S., Paterson, A., … Verma, S. (2008). Cardiac management during adjuvant trastuzumab therapy: Recommendations of the Canadian Trastuzumab Working Group. Current Oncology, 15(1), 24–35. https://doi.org/10.3747/co.2008.199
Mackey, J. R., M. Clemons, M. A. Côté, D. Delgado, S. Dent, A. Paterson, L. Provencher, M. B. Sawyer, and S. Verma. “Cardiac management during adjuvant trastuzumab therapy: Recommendations of the Canadian Trastuzumab Working Group.” Current Oncology 15, no. 1 (January 1, 2008): 24–35. https://doi.org/10.3747/co.2008.199.
Mackey JR, Clemons M, Côté MA, Delgado D, Dent S, Paterson A, et al. Cardiac management during adjuvant trastuzumab therapy: Recommendations of the Canadian Trastuzumab Working Group. Current Oncology. 2008 Jan 1;15(1):24–35.
Mackey, J. R., et al. “Cardiac management during adjuvant trastuzumab therapy: Recommendations of the Canadian Trastuzumab Working Group.” Current Oncology, vol. 15, no. 1, Jan. 2008, pp. 24–35. Scopus, doi:10.3747/co.2008.199.
Mackey JR, Clemons M, Côté MA, Delgado D, Dent S, Paterson A, Provencher L, Sawyer MB, Verma S. Cardiac management during adjuvant trastuzumab therapy: Recommendations of the Canadian Trastuzumab Working Group. Current Oncology. 2008 Jan 1;15(1):24–35.

Published In

Current Oncology

DOI

EISSN

1718-7729

Publication Date

January 1, 2008

Volume

15

Issue

1

Start / End Page

24 / 35

Related Subject Headings

  • Oncology & Carcinogenesis
  • 3211 Oncology and carcinogenesis
  • 1112 Oncology and Carcinogenesis