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Acquisition of metastatic tissue from patients with bone metastases from breast cancer.

Publication ,  Journal Article
Hilton, JF; Amir, E; Hopkins, S; Nabavi, M; DiPrimio, G; Sheikh, A; Done, SJ; Gianfelice, D; Kanji, F; Dent, S; Barth, D; Bouganim, N ...
Published in: Breast Cancer Res Treat
October 2011

Biopsies of metastatic tissue are increasingly being performed. Bone is the most frequent site of metastasis in breast cancer patients, but bone remains technically challenging to biopsy. Difficulties with both tissue acquisition and techniques for analysis of hormone receptor status are well described. Bone biopsies can be carried out by either by standard posterior iliac crest bone marrow trephine/aspiration or CT-guided biopsy of a radiologically evident bone metastasis. The differential yield of these techniques is unknown. Results from three prospective studies of similar methodology were pooled. Patients underwent both an outpatient posterior iliac crest bone marrow trephine/aspiration and a CT-guided biopsy of a radiologically evident bone metastasis. Samples were assessed for the presence of malignant cells and where possible also for estrogen (ER) and progesterone receptor (PgR) expression. 40 patients were enrolled. Bone marrow aspiration/trephine biopsy was completed in 39/40 (97.5%) and CT-guided biopsy was completed in 34/40 (85%) of patients. Sufficient tumor cells for hormone receptor analysis were available in 19/39 (48.8%) and 16/34 (47%) of and bone marrow aspiration/trephine and CT-guided biopsies, respectively. Significant discordance in ER and PgR between the primary and the bone metastasis was also seen. Nine patients had tissue available from both bone marrow and CT-guided bone biopsies. ER and PgR concordance between these sites was 100 and 78%, respectively. Performing studies on human bone metastases is technically challenging, with relatively low yields regardless of technique. Given resource issues and similar success rates when comparing both techniques, bone marrow examination may be utilized first and if inadequate tissue is obtained, CT-guided biopsies can then be used.

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Published In

Breast Cancer Res Treat

DOI

EISSN

1573-7217

Publication Date

October 2011

Volume

129

Issue

3

Start / End Page

761 / 765

Location

Netherlands

Related Subject Headings

  • Tomography, X-Ray Computed
  • Receptors, Progesterone
  • Receptors, Estrogen
  • Oncology & Carcinogenesis
  • Middle Aged
  • Humans
  • Female
  • Breast Neoplasms
  • Bone Neoplasms
  • Bone Marrow Examination
 

Citation

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Hilton, J. F., Amir, E., Hopkins, S., Nabavi, M., DiPrimio, G., Sheikh, A., … Clemons, M. (2011). Acquisition of metastatic tissue from patients with bone metastases from breast cancer. Breast Cancer Res Treat, 129(3), 761–765. https://doi.org/10.1007/s10549-010-1264-6
Hilton, J. F., E. Amir, S. Hopkins, M. Nabavi, G. DiPrimio, A. Sheikh, S. J. Done, et al. “Acquisition of metastatic tissue from patients with bone metastases from breast cancer.Breast Cancer Res Treat 129, no. 3 (October 2011): 761–65. https://doi.org/10.1007/s10549-010-1264-6.
Hilton JF, Amir E, Hopkins S, Nabavi M, DiPrimio G, Sheikh A, et al. Acquisition of metastatic tissue from patients with bone metastases from breast cancer. Breast Cancer Res Treat. 2011 Oct;129(3):761–5.
Hilton, J. F., et al. “Acquisition of metastatic tissue from patients with bone metastases from breast cancer.Breast Cancer Res Treat, vol. 129, no. 3, Oct. 2011, pp. 761–65. Pubmed, doi:10.1007/s10549-010-1264-6.
Hilton JF, Amir E, Hopkins S, Nabavi M, DiPrimio G, Sheikh A, Done SJ, Gianfelice D, Kanji F, Dent S, Barth D, Bouganim N, Al-Najjar A, Clemons M. Acquisition of metastatic tissue from patients with bone metastases from breast cancer. Breast Cancer Res Treat. 2011 Oct;129(3):761–765.
Journal cover image

Published In

Breast Cancer Res Treat

DOI

EISSN

1573-7217

Publication Date

October 2011

Volume

129

Issue

3

Start / End Page

761 / 765

Location

Netherlands

Related Subject Headings

  • Tomography, X-Ray Computed
  • Receptors, Progesterone
  • Receptors, Estrogen
  • Oncology & Carcinogenesis
  • Middle Aged
  • Humans
  • Female
  • Breast Neoplasms
  • Bone Neoplasms
  • Bone Marrow Examination