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Effect of oral antiviral treatment on long-term outcomes of radiofrequency ablation therapy for hepatitis B virus-related hepatocellular carcinoma.

Publication ,  Journal Article
Sohn, W; Kang, TW; Choi, S-K; Jung, S-H; Lee, MW; Lim, HK; Cho, J-Y; Shim, SG; Sinn, DH; Gwak, G-Y; Choi, MS; Lee, JH; Koh, KC; Paik, SW ...
Published in: Oncotarget
July 26, 2016

OBJECTIVES: This study aimed to investigate the effect of oral antiviral treatment on the prognosis of hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) after radiofrequency (RF) ablation. METHODS: Between January 2003 and December 2010, 228 patients without a history of antiviral treatment were treated with RF ablation for a single HBV-related HCC. We divided the patients into two groups, patients who received (n=125) or did not receive antiviral treatment (n=103), based on whether oral antiviral treatment was administered after RF ablation. The median duration of antiviral treatment was 60.1 months. HCC recurrence and overall survival were compared in the two groups in the full cohort and the propensity score-matched cohort. RESULTS: In the matched cohort, the probability of HCC recurrence at 5 years was 43.8% for the non-antiviral treatment group and 14.7% for the antiviral treatment group (p<0.001). The probability of overall survival at 5 years was 77.2% for the non-antiviral treatment group and 93.5% for the antiviral treatment group (p=0.002). Multivariable analysis showed that risk factors for HCC recurrence included large tumor size (hazard ratio (HR)=1.30, p=0.022), HBV DNA serum level (HR=1.11, p=0.005), and serum AFP level ≥20 ng/mL (HR=1.66, p=0.005). Overall survival was associated with larger tumor size (HR=1.86, p=0.001) and Child-Pugh Class B (HR=2.13, p=0.019). Oral antiviral treatment after RF ablation was significantly associated with a lower risk of tumor recurrence and death (HR=0.33, p<0.001, and HR=0.44, p=0.004). CONCLUSION: Use of oral antiviral treatment after curative RF ablation was associated with favorable outcomes in terms of tumor recurrence and overall survival in patients with HBV-related HCC.

Duke Scholars

Published In

Oncotarget

DOI

EISSN

1949-2553

Publication Date

July 26, 2016

Volume

7

Issue

30

Start / End Page

47794 / 47807

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Retrospective Studies
  • Prognosis
  • Neoplasm Recurrence, Local
  • Middle Aged
  • Male
  • Liver Neoplasms
  • Humans
  • Hepatitis B, Chronic
  • Hepatitis B virus
 

Citation

APA
Chicago
ICMJE
MLA
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Sohn, W., Kang, T. W., Choi, S.-K., Jung, S.-H., Lee, M. W., Lim, H. K., … Paik, Y.-H. (2016). Effect of oral antiviral treatment on long-term outcomes of radiofrequency ablation therapy for hepatitis B virus-related hepatocellular carcinoma. Oncotarget, 7(30), 47794–47807. https://doi.org/10.18632/oncotarget.10026
Sohn, Won, Tae Wook Kang, Sun-Kyu Choi, Sin-Ho Jung, Min Woo Lee, Hyo Keun Lim, Ju-Yeon Cho, et al. “Effect of oral antiviral treatment on long-term outcomes of radiofrequency ablation therapy for hepatitis B virus-related hepatocellular carcinoma.Oncotarget 7, no. 30 (July 26, 2016): 47794–807. https://doi.org/10.18632/oncotarget.10026.
Sohn W, Kang TW, Choi S-K, Jung S-H, Lee MW, Lim HK, et al. Effect of oral antiviral treatment on long-term outcomes of radiofrequency ablation therapy for hepatitis B virus-related hepatocellular carcinoma. Oncotarget. 2016 Jul 26;7(30):47794–807.
Sohn, Won, et al. “Effect of oral antiviral treatment on long-term outcomes of radiofrequency ablation therapy for hepatitis B virus-related hepatocellular carcinoma.Oncotarget, vol. 7, no. 30, July 2016, pp. 47794–807. Pubmed, doi:10.18632/oncotarget.10026.
Sohn W, Kang TW, Choi S-K, Jung S-H, Lee MW, Lim HK, Cho J-Y, Shim SG, Sinn DH, Gwak G-Y, Choi MS, Lee JH, Koh KC, Paik SW, Rhim H, Paik Y-H. Effect of oral antiviral treatment on long-term outcomes of radiofrequency ablation therapy for hepatitis B virus-related hepatocellular carcinoma. Oncotarget. 2016 Jul 26;7(30):47794–47807.

Published In

Oncotarget

DOI

EISSN

1949-2553

Publication Date

July 26, 2016

Volume

7

Issue

30

Start / End Page

47794 / 47807

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Retrospective Studies
  • Prognosis
  • Neoplasm Recurrence, Local
  • Middle Aged
  • Male
  • Liver Neoplasms
  • Humans
  • Hepatitis B, Chronic
  • Hepatitis B virus