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A motion prediction confidence estimation framework for prediction-based radiotherapy gating.

Publication ,  Journal Article
Ginn, JS; Low, DA; Lamb, JM; Ruan, D
Published in: Med Phys
August 2020

PURPOSE: Motion prediction can compensate for latency in image-guided radiotherapy and has been an active area of research. However, motion predictions are subject to error and variations. We have developed and evaluated a novel motion prediction confidence estimation framework to improve the efficacy and robustness of prediction-based radiotherapy gating decision-making. The specific scenario of adaptive gating in magnetic resonance imaging (MRI)-guided radiotherapy is studied as an example, but the method generalizes to other modalities and motion management setups. METHODS: The proposed prediction confidence estimator is based on a generic training/testing paradigm and consists of a weighted combination of three components: the prediction model's goodness of fit, variation in the prediction using a leave-one-out process and the velocity of the tracked target. Roughly, these terms quantify respectively the consistency between prediction and the training data, the robustness of model inference, and the stability due to target speed. The weight parameters and the action level in triggering beam-off decision are optimized. The method is assessed and validated in 8 healthy volunteer and 13 patient studies using a 0.35T MRI-guided radiotherapy system predicting 0.25-0.33 s ahead. The effect of the action level on the predicted gating decision accuracy, beam-on positive predictive value (PPV) and median distance between the predicted and ground-truth target centroids were evaluated. Statistical significance was evaluated using a paired t-test. The tradeoff between these performance metrics and gating duty cycle was assessed. RESULTS: Use of the confidence estimator threshold increased gating accuracy by up to 2.42%, increased PPV by up to 3.00%, and reduced the median centroid distance up to 0.28 mm. The confidence estimator threshold on average increased gating accuracy to 96.5% (P = 2.08 × 10-4 ), increased PPV to 96.7% (P = 1.46 × 10-5 ), reduced the median centroid distance to 0.54 mm (P = 1.71 × 10-5 ) at the cost of reducing the gating duty cycle by 14.3% to 48.5%. Hyperparameter tuning revealed that contrary to intuition, the velocity term offered only minimal performance improvement in some cases but also introduced potential stability issues. The combination of goodness of fit and leave-one-out prediction variation provided the most effective confidence estimator, yielding universally better performance in gating decisions. CONCLUSION: Confidence estimation utilizing prediction model fitness criterion and validation principles can complement prediction methods to guide MRI-guided radiotherapy gating. Results from both volunteer and patient studies showed improved gating quality.

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Published In

Med Phys

DOI

EISSN

2473-4209

Publication Date

August 2020

Volume

47

Issue

8

Start / End Page

3297 / 3304

Location

United States

Related Subject Headings

  • Respiration
  • Radiotherapy, Image-Guided
  • Radiotherapy, Computer-Assisted
  • Nuclear Medicine & Medical Imaging
  • Movement
  • Motion
  • Humans
  • 5105 Medical and biological physics
  • 4003 Biomedical engineering
  • 1112 Oncology and Carcinogenesis
 

Citation

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Ginn, J. S., Low, D. A., Lamb, J. M., & Ruan, D. (2020). A motion prediction confidence estimation framework for prediction-based radiotherapy gating. Med Phys, 47(8), 3297–3304. https://doi.org/10.1002/mp.14236
Ginn, John S., Daniel A. Low, James M. Lamb, and Dan Ruan. “A motion prediction confidence estimation framework for prediction-based radiotherapy gating.Med Phys 47, no. 8 (August 2020): 3297–3304. https://doi.org/10.1002/mp.14236.
Ginn JS, Low DA, Lamb JM, Ruan D. A motion prediction confidence estimation framework for prediction-based radiotherapy gating. Med Phys. 2020 Aug;47(8):3297–304.
Ginn, John S., et al. “A motion prediction confidence estimation framework for prediction-based radiotherapy gating.Med Phys, vol. 47, no. 8, Aug. 2020, pp. 3297–304. Pubmed, doi:10.1002/mp.14236.
Ginn JS, Low DA, Lamb JM, Ruan D. A motion prediction confidence estimation framework for prediction-based radiotherapy gating. Med Phys. 2020 Aug;47(8):3297–3304.

Published In

Med Phys

DOI

EISSN

2473-4209

Publication Date

August 2020

Volume

47

Issue

8

Start / End Page

3297 / 3304

Location

United States

Related Subject Headings

  • Respiration
  • Radiotherapy, Image-Guided
  • Radiotherapy, Computer-Assisted
  • Nuclear Medicine & Medical Imaging
  • Movement
  • Motion
  • Humans
  • 5105 Medical and biological physics
  • 4003 Biomedical engineering
  • 1112 Oncology and Carcinogenesis