Abeloff’s Clinical Oncology
DNA Damage Response Pathways and Cancer
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, Chapter
Ford, JM; Kastan, MB
January 1, 2019
DNA repair and the cellular response to DNA damage are critical for maintaining genomic stability. Defects in DNA repair or the response to DNA damage encountered from endogenous or external sources results in an increased rate of genetic mutations, often leading to the development of cancer. Inherited mutations in DNA damage response pathway genes often result in cancer susceptibility. The major active pathways for DNA repair in humans are nucleotide excision repair, base excision repair, mismatch DNA repair, translesional DNA synthesis, and homologous recombination or nonhomologous end joining processes for double-strand break repair.
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DOI
Publication Date
January 1, 2019
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154 / 164.e4
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Ford, J. M., & Kastan, M. B. (2019). DNA Damage Response Pathways and Cancer. In Abeloff’s Clinical Oncology (pp. 154-164.e4). https://doi.org/10.1016/B978-0-323-47674-4.00011-6
Ford, J. M., and M. B. Kastan. “DNA Damage Response Pathways and Cancer.” In Abeloff’s Clinical Oncology, 154-164.e4, 2019. https://doi.org/10.1016/B978-0-323-47674-4.00011-6.
Ford JM, Kastan MB. DNA Damage Response Pathways and Cancer. In: Abeloff’s Clinical Oncology. 2019. p. 154-164.e4.
Ford, J. M., and M. B. Kastan. “DNA Damage Response Pathways and Cancer.” Abeloff’s Clinical Oncology, 2019, pp. 154-164.e4. Scopus, doi:10.1016/B978-0-323-47674-4.00011-6.
Ford JM, Kastan MB. DNA Damage Response Pathways and Cancer. Abeloff’s Clinical Oncology. 2019. p. 154-164.e4.
DOI
Publication Date
January 1, 2019
Start / End Page
154 / 164.e4