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Anti-RNP antibodies are associated with the interferon gene signature but not decreased complement levels in SLE.

Publication ,  Journal Article
Hubbard, EL; Pisetsky, DS; Lipsky, PE
Published in: Ann Rheum Dis
May 2022

OBJECTIVES: The goals of these studies were to elucidate the inter-relationships of specific anti-nuclear antibody (ANA), complement, and the interferon gene signature (IGS) in the pathogenesis of systemic lupus erythematosus (SLE). METHODS: Data from the Illuminate trials were analysed for antibodies to dsDNA as well as RNA-binding proteins (RBP), levels of C3, C4 and various IGS. Statistical hypothesis testing, linear regression analyses and classification and regression trees analysis were employed to assess relationships between the laboratory features of SLE. RESULTS: Inter-relationships of ANAs, complement and the IGS differed between patients of African Ancestry (AA) and European Ancestry (EA); anti-RNP and multiple autoantibodies were more common in AA patients and, although both related to the presence of the IGS, relationships between autoantibodies and complement differed. Whereas, anti-dsDNA had an inverse relationship to C3 and C4, levels of anti-RNP were not related to these markers. The IGS was only correlated with anti-dsDNA in EA SLE and complement was more correlated to the IGS in AA SLE. Finally, autoantibodies occurred in the presence and absence of the IGS, whereas the IGS was infrequent in anti-dsDNA/anti-RBP-negative SLE patients. CONCLUSION: There is a complex relationship between autoantibodies and the IGS, with anti-RNP associated in AA and both anti-dsDNA and RNP associated in EA. Moreover, there was a difference in the relationship between anti-dsDNA, but not anti-RBP, with complement levels. The lack of a relationship of anti-RNP with C3 and C4 suggests that anti-RNP immune complexes (ICs) may drive the IGS without complement fixation, whereas anti-dsDNA ICs involve complement consumption.

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Published In

Ann Rheum Dis

DOI

EISSN

1468-2060

Publication Date

May 2022

Volume

81

Issue

5

Start / End Page

632 / 643

Location

England

Related Subject Headings

  • Lupus Erythematosus, Systemic
  • Interferons
  • Humans
  • DNA
  • Complement C4
  • Complement C3
  • Autoantibodies
  • Arthritis & Rheumatology
  • Antiviral Agents
  • Antigen-Antibody Complex
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Hubbard, E. L., Pisetsky, D. S., & Lipsky, P. E. (2022). Anti-RNP antibodies are associated with the interferon gene signature but not decreased complement levels in SLE. Ann Rheum Dis, 81(5), 632–643. https://doi.org/10.1136/annrheumdis-2021-221662
Hubbard, Erika L., David S. Pisetsky, and Peter E. Lipsky. “Anti-RNP antibodies are associated with the interferon gene signature but not decreased complement levels in SLE.Ann Rheum Dis 81, no. 5 (May 2022): 632–43. https://doi.org/10.1136/annrheumdis-2021-221662.
Hubbard EL, Pisetsky DS, Lipsky PE. Anti-RNP antibodies are associated with the interferon gene signature but not decreased complement levels in SLE. Ann Rheum Dis. 2022 May;81(5):632–43.
Hubbard, Erika L., et al. “Anti-RNP antibodies are associated with the interferon gene signature but not decreased complement levels in SLE.Ann Rheum Dis, vol. 81, no. 5, May 2022, pp. 632–43. Pubmed, doi:10.1136/annrheumdis-2021-221662.
Hubbard EL, Pisetsky DS, Lipsky PE. Anti-RNP antibodies are associated with the interferon gene signature but not decreased complement levels in SLE. Ann Rheum Dis. 2022 May;81(5):632–643.

Published In

Ann Rheum Dis

DOI

EISSN

1468-2060

Publication Date

May 2022

Volume

81

Issue

5

Start / End Page

632 / 643

Location

England

Related Subject Headings

  • Lupus Erythematosus, Systemic
  • Interferons
  • Humans
  • DNA
  • Complement C4
  • Complement C3
  • Autoantibodies
  • Arthritis & Rheumatology
  • Antiviral Agents
  • Antigen-Antibody Complex