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Association of Treatable Health Conditions During Adolescence With Accelerated Aging at Midlife.

Publication ,  Journal Article
Bourassa, KJ; Moffitt, TE; Ambler, A; Hariri, AR; Harrington, H; Houts, RM; Ireland, D; Knodt, A; Poulton, R; Ramrakha, S; Caspi, A
Published in: JAMA pediatrics
April 2022

Biological aging is a distinct construct from health; however, people who age quickly are more likely to experience poor health. Identifying pediatric health conditions associated with accelerated aging could help develop treatment approaches to slow midlife aging and prevent poor health in later life.To examine the association between 4 treatable health conditions in adolescence and accelerated aging at midlife.This cohort study analyzed data from participants in the Dunedin Study, a longitudinal investigation of health and behavior among a birth cohort born between April 1, 1972, and March 31, 1973, in Dunedin, New Zealand, and followed up until age 45 years. Participants underwent an assessment at age 45 years and had data for at least 1 adolescent health condition (asthma, smoking, obesity, and psychological disorders) and outcome measure (pace of aging, gait speed, brain age, and facial age). Data analysis was performed from February 11 to September 27, 2021.Asthma, cigarette smoking, obesity, and psychological disorders were assessed at age 11, 13, and 15 years.The outcome was a midlife aging factor composite score comprising 4 measures of biological aging: pace of aging, gait speed, brain age (specifically, BrainAGE score), and facial age.A total of 910 participants (459 men [50.4%]) met the inclusion criteria, including an assessment at age 45 years. Participants who had smoked daily (0.61 [95% CI, 0.43-0.79] SD units), had obesity (0.82 [95% CI, 0.59-1.06] SD units), or had a psychological disorder diagnosis (0.43 [95% CI, 0.29-0.56] SD units) during adolescence were biologically older at midlife compared with participants without these conditions. Participants with asthma were not biologically older at midlife (0.02 [95% CI, -0.14 to 0.19] SD units) compared with those without asthma. These results remained unchanged after adjusting for childhood risk factors such as poor health, socioeconomic disadvantage, and adverse experiences.This study found that adolescent smoking, obesity, and psychological disorder diagnoses were associated with older biological age at midlife. These health conditions could be treated during adolescence to reduce the risk of accelerated biological aging later in life.

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Published In

JAMA pediatrics

DOI

EISSN

2168-6211

ISSN

2168-6203

Publication Date

April 2022

Volume

176

Issue

4

Start / End Page

392 / 399

Related Subject Headings

  • Risk Factors
  • Pediatrics
  • Middle Aged
  • Mental Disorders
  • Male
  • Longitudinal Studies
  • Humans
  • Cohort Studies
  • Child
  • Brain
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Bourassa, K. J., Moffitt, T. E., Ambler, A., Hariri, A. R., Harrington, H., Houts, R. M., … Caspi, A. (2022). Association of Treatable Health Conditions During Adolescence With Accelerated Aging at Midlife. JAMA Pediatrics, 176(4), 392–399. https://doi.org/10.1001/jamapediatrics.2021.6417
Bourassa, Kyle J., Terrie E. Moffitt, Antony Ambler, Ahmad R. Hariri, HonaLee Harrington, Renate M. Houts, David Ireland, et al. “Association of Treatable Health Conditions During Adolescence With Accelerated Aging at Midlife.JAMA Pediatrics 176, no. 4 (April 2022): 392–99. https://doi.org/10.1001/jamapediatrics.2021.6417.
Bourassa KJ, Moffitt TE, Ambler A, Hariri AR, Harrington H, Houts RM, et al. Association of Treatable Health Conditions During Adolescence With Accelerated Aging at Midlife. JAMA pediatrics. 2022 Apr;176(4):392–9.
Bourassa, Kyle J., et al. “Association of Treatable Health Conditions During Adolescence With Accelerated Aging at Midlife.JAMA Pediatrics, vol. 176, no. 4, Apr. 2022, pp. 392–99. Epmc, doi:10.1001/jamapediatrics.2021.6417.
Bourassa KJ, Moffitt TE, Ambler A, Hariri AR, Harrington H, Houts RM, Ireland D, Knodt A, Poulton R, Ramrakha S, Caspi A. Association of Treatable Health Conditions During Adolescence With Accelerated Aging at Midlife. JAMA pediatrics. 2022 Apr;176(4):392–399.

Published In

JAMA pediatrics

DOI

EISSN

2168-6211

ISSN

2168-6203

Publication Date

April 2022

Volume

176

Issue

4

Start / End Page

392 / 399

Related Subject Headings

  • Risk Factors
  • Pediatrics
  • Middle Aged
  • Mental Disorders
  • Male
  • Longitudinal Studies
  • Humans
  • Cohort Studies
  • Child
  • Brain