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Coronary volume to left ventricular mass ratio in patients with diabetes mellitus.

Publication ,  Journal Article
Kuneman, JH; El Mahdiui, M; van Rosendael, AR; van den Hoogen, IJ; Patel, MR; Nørgaard, BL; Fairbairn, TA; Nieman, K; Akasaka, T; Berman, DS ...
Published in: J Cardiovasc Comput Tomogr
2022

BACKGROUND: Diabetes mellitus is a major risk factor for coronary artery disease (CAD) and may provoke structural and functional changes in coronary vasculature. The coronary volume to left ventricular mass (V/M) ratio is a new anatomical parameter capable of revealing a potential physiological imbalance between coronary vasculature and myocardial mass. The aim of this study was to examine the V/M derived from coronary computed tomography angiography (CCTA) in patients with diabetes. METHODS: Patients with clinically suspected CAD enrolled in the ADVANCE (Assessing Diagnostic Value of Non-invasive FFRCT in Coronary Care) registry and known diabetic status were included. Coronary artery volume and left ventricular myocardial mass were analyzed from CCTA and the V/M ratio was calculated and compared between patients with and without diabetes. RESULTS: Of the 3053 patients (age 66 ​± ​10 years; 66% male) with known diabetic status, diabetes was present in 21.9%. Coronary volume was lower in patients with diabetes compared to those without diabetes (2850 ​± ​940 ​mm3 vs. 3040 ​± ​970 ​mm3, p ​< ​0.0001), whereas the myocardial mass was comparable between the 2 groups (122 ​± ​33 ​g vs. 122 ​± ​32 ​g, p ​= ​0.70). The V/M ratio was significantly lower in patients with diabetes (23.9 ​± ​6.8 ​mm3/g vs. 25.7 ​± ​7.5 ​mm3/g, p ​< ​0.0001). Among subjects with obstructive CAD (n ​= ​2191, 24.0% diabetics) and non-obstructive CAD (16.7% diabetics), the V/M ratio was significantly lower in patients with diabetes compared to those without (23.4 ​± ​6.7 ​mm3/g vs. 25.0 ​± ​7.3 ​mm3/g, p ​< ​0.0001 and 25.6 ​± ​6.9 ​mm3/g vs. 27.3 ​± ​7.6 ​mm3/g, respectively, p ​= ​0.006). CONCLUSION: The V/M ratio was significantly lower in patients with diabetes compared to non-diabetics, even after correcting for obstructive coronary stenosis. The clinical value of the reduced V/M ratio in diabetic patients needs further investigation.

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Published In

J Cardiovasc Comput Tomogr

DOI

EISSN

1876-861X

Publication Date

2022

Volume

16

Issue

4

Start / End Page

319 / 326

Location

United States

Related Subject Headings

  • Predictive Value of Tests
  • Middle Aged
  • Male
  • Humans
  • Female
  • Diabetes Mellitus
  • Coronary Stenosis
  • Coronary Artery Disease
  • Coronary Angiography
  • Computed Tomography Angiography
 

Citation

APA
Chicago
ICMJE
MLA
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Kuneman, J. H., El Mahdiui, M., van Rosendael, A. R., van den Hoogen, I. J., Patel, M. R., Nørgaard, B. L., … Knuuti, J. (2022). Coronary volume to left ventricular mass ratio in patients with diabetes mellitus. J Cardiovasc Comput Tomogr, 16(4), 319–326. https://doi.org/10.1016/j.jcct.2022.01.004
Kuneman, Jurrien H., Mohammed El Mahdiui, Alexander R. van Rosendael, Inge J. van den Hoogen, Manesh R. Patel, Bjarne Linde Nørgaard, Timothy A. Fairbairn, et al. “Coronary volume to left ventricular mass ratio in patients with diabetes mellitus.J Cardiovasc Comput Tomogr 16, no. 4 (2022): 319–26. https://doi.org/10.1016/j.jcct.2022.01.004.
Kuneman JH, El Mahdiui M, van Rosendael AR, van den Hoogen IJ, Patel MR, Nørgaard BL, et al. Coronary volume to left ventricular mass ratio in patients with diabetes mellitus. J Cardiovasc Comput Tomogr. 2022;16(4):319–26.
Kuneman, Jurrien H., et al. “Coronary volume to left ventricular mass ratio in patients with diabetes mellitus.J Cardiovasc Comput Tomogr, vol. 16, no. 4, 2022, pp. 319–26. Pubmed, doi:10.1016/j.jcct.2022.01.004.
Kuneman JH, El Mahdiui M, van Rosendael AR, van den Hoogen IJ, Patel MR, Nørgaard BL, Fairbairn TA, Nieman K, Akasaka T, Berman DS, Hurwitz Koweek LM, Pontone G, Kawasaki T, Rønnow Sand NP, Jensen JM, Amano T, Poon M, Øvrehus KA, Sonck J, Rabbat MG, De Bruyne B, Rogers C, Matsuo H, Bax JJ, Leipsic JA, Knuuti J. Coronary volume to left ventricular mass ratio in patients with diabetes mellitus. J Cardiovasc Comput Tomogr. 2022;16(4):319–326.
Journal cover image

Published In

J Cardiovasc Comput Tomogr

DOI

EISSN

1876-861X

Publication Date

2022

Volume

16

Issue

4

Start / End Page

319 / 326

Location

United States

Related Subject Headings

  • Predictive Value of Tests
  • Middle Aged
  • Male
  • Humans
  • Female
  • Diabetes Mellitus
  • Coronary Stenosis
  • Coronary Artery Disease
  • Coronary Angiography
  • Computed Tomography Angiography