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Sexual Dimorphism in Cardiovascular Biomarkers: Clinical and Research Implications.

Publication ,  Journal Article
Lau, ES; Binek, A; Parker, SJ; Shah, SH; Zanni, MV; Van Eyk, JE; Ho, JE
Published in: Circ Res
February 18, 2022

Sex-based differences in cardiovascular disease presentation, diagnosis, and response to therapies are well established, but mechanistic understanding and translation to clinical applications are limited. Blood-based biomarkers have become an important tool for interrogating biologic pathways. Understanding sexual dimorphism in the relationship between biomarkers and cardiovascular disease will enhance our insights into cardiovascular disease pathogenesis in women, with potential to translate to improved individualized care for men and women with or at risk for cardiovascular disease. In this review, we examine how biologic sex associates with differential levels of blood-based biomarkers and influences the effect of biomarkers on disease outcomes. We further summarize key differences in blood-based cardiovascular biomarkers along central biologic pathways, including myocardial stretch/injury, inflammation, adipose tissue metabolism, and fibrosis pathways in men versus women. Finally, we present recommendations for leveraging our current knowledge of sex differences in blood-based biomarkers for future research and clinical innovation.

Duke Scholars

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Published In

Circ Res

DOI

EISSN

1524-4571

Publication Date

February 18, 2022

Volume

130

Issue

4

Start / End Page

578 / 592

Location

United States

Related Subject Headings

  • Sex Characteristics
  • Risk Factors
  • Inflammation Mediators
  • Humans
  • Cardiovascular System & Hematology
  • Cardiovascular Diseases
  • Biomarkers
  • Adipose Tissue
  • 3202 Clinical sciences
  • 3201 Cardiovascular medicine and haematology
 

Citation

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Lau, E. S., Binek, A., Parker, S. J., Shah, S. H., Zanni, M. V., Van Eyk, J. E., & Ho, J. E. (2022). Sexual Dimorphism in Cardiovascular Biomarkers: Clinical and Research Implications. Circ Res, 130(4), 578–592. https://doi.org/10.1161/CIRCRESAHA.121.319916
Lau, Emily S., Aleksandra Binek, Sarah J. Parker, Svati H. Shah, Markella V. Zanni, Jennifer E. Van Eyk, and Jennifer E. Ho. “Sexual Dimorphism in Cardiovascular Biomarkers: Clinical and Research Implications.Circ Res 130, no. 4 (February 18, 2022): 578–92. https://doi.org/10.1161/CIRCRESAHA.121.319916.
Lau ES, Binek A, Parker SJ, Shah SH, Zanni MV, Van Eyk JE, et al. Sexual Dimorphism in Cardiovascular Biomarkers: Clinical and Research Implications. Circ Res. 2022 Feb 18;130(4):578–92.
Lau, Emily S., et al. “Sexual Dimorphism in Cardiovascular Biomarkers: Clinical and Research Implications.Circ Res, vol. 130, no. 4, Feb. 2022, pp. 578–92. Pubmed, doi:10.1161/CIRCRESAHA.121.319916.
Lau ES, Binek A, Parker SJ, Shah SH, Zanni MV, Van Eyk JE, Ho JE. Sexual Dimorphism in Cardiovascular Biomarkers: Clinical and Research Implications. Circ Res. 2022 Feb 18;130(4):578–592.

Published In

Circ Res

DOI

EISSN

1524-4571

Publication Date

February 18, 2022

Volume

130

Issue

4

Start / End Page

578 / 592

Location

United States

Related Subject Headings

  • Sex Characteristics
  • Risk Factors
  • Inflammation Mediators
  • Humans
  • Cardiovascular System & Hematology
  • Cardiovascular Diseases
  • Biomarkers
  • Adipose Tissue
  • 3202 Clinical sciences
  • 3201 Cardiovascular medicine and haematology