Skip to main content
construction release_alert
Scholars@Duke will be undergoing maintenance April 11-15. Some features may be unavailable during this time.
cancel

Technologies for Frugal and Sensitive Point-of-Care Immunoassays.

Publication ,  Journal Article
Kinnamon, DS; Heggestad, JT; Liu, J; Chilkoti, A
Published in: Annual review of analytical chemistry (Palo Alto, Calif.)
June 2022

Immunoassays are a powerful tool for sensitive and quantitative analysis of a wide range of biomolecular analytes in the clinic and in research laboratories. However, enzyme-linked immunosorbent assay (ELISA)-the gold-standard assay-requires significant user intervention, time, and clinical resources, making its deployment at the point-of-care (POC) impractical. Researchers have made great strides toward democratizing access to clinical quality immunoassays at the POC and at an affordable price. In this review, we first summarize the commercially available options that offer high performance, albeit at high cost. Next, we describe strategies for the development of frugal POC assays that repurpose consumer electronics and smartphones for the quantitative detection of analytes. Finally, we discuss innovative assay formats that enable highly sensitive analysis in the field with simple instrumentation.

Duke Scholars

Published In

Annual review of analytical chemistry (Palo Alto, Calif.)

DOI

EISSN

1936-1335

ISSN

1936-1327

Publication Date

June 2022

Volume

15

Issue

1

Start / End Page

123 / 149

Related Subject Headings

  • Smartphone
  • Point-of-Care Testing
  • Point-of-Care Systems
  • Immunoassay
  • Enzyme-Linked Immunosorbent Assay
  • Biological Assay
  • Analytical Chemistry
  • 3401 Analytical chemistry
  • 0399 Other Chemical Sciences
  • 0301 Analytical Chemistry
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Kinnamon, D. S., Heggestad, J. T., Liu, J., & Chilkoti, A. (2022). Technologies for Frugal and Sensitive Point-of-Care Immunoassays. Annual Review of Analytical Chemistry (Palo Alto, Calif.), 15(1), 123–149. https://doi.org/10.1146/annurev-anchem-061020-123817
Kinnamon, David S., Jacob T. Heggestad, Jason Liu, and Ashutosh Chilkoti. “Technologies for Frugal and Sensitive Point-of-Care Immunoassays.Annual Review of Analytical Chemistry (Palo Alto, Calif.) 15, no. 1 (June 2022): 123–49. https://doi.org/10.1146/annurev-anchem-061020-123817.
Kinnamon DS, Heggestad JT, Liu J, Chilkoti A. Technologies for Frugal and Sensitive Point-of-Care Immunoassays. Annual review of analytical chemistry (Palo Alto, Calif). 2022 Jun;15(1):123–49.
Kinnamon, David S., et al. “Technologies for Frugal and Sensitive Point-of-Care Immunoassays.Annual Review of Analytical Chemistry (Palo Alto, Calif.), vol. 15, no. 1, June 2022, pp. 123–49. Epmc, doi:10.1146/annurev-anchem-061020-123817.
Kinnamon DS, Heggestad JT, Liu J, Chilkoti A. Technologies for Frugal and Sensitive Point-of-Care Immunoassays. Annual review of analytical chemistry (Palo Alto, Calif). 2022 Jun;15(1):123–149.

Published In

Annual review of analytical chemistry (Palo Alto, Calif.)

DOI

EISSN

1936-1335

ISSN

1936-1327

Publication Date

June 2022

Volume

15

Issue

1

Start / End Page

123 / 149

Related Subject Headings

  • Smartphone
  • Point-of-Care Testing
  • Point-of-Care Systems
  • Immunoassay
  • Enzyme-Linked Immunosorbent Assay
  • Biological Assay
  • Analytical Chemistry
  • 3401 Analytical chemistry
  • 0399 Other Chemical Sciences
  • 0301 Analytical Chemistry