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The Sickle Cell Disease Functional Assessment (SCD-FA) tool: a feasibility pilot study.

Publication ,  Journal Article
Oyedeji, CI; Hall, K; Luciano, A; Morey, MC; Strouse, JJ
Published in: Pilot and feasibility studies
March 2022

The life expectancy for individuals with sickle cell disease (SCD) has greatly increased over the last 50 years. Adults with SCD experience multiple complications such as cardiopulmonary disease, strokes, and avascular necrosis that lead to limitations that geriatric populations often experience. There are no dedicated instruments to measure functional decline and functional age to determine risk of future adverse outcomes in older adults with SCD. The objective of this study was to assess the feasibility of performing the Sickle Cell Disease Functional Assessment (SCD-FA).We enrolled 40 adults with SCD (20 younger adults aged 18-49 years as a comparison group and 20 older adults aged 50 years and older) in a single-center prospective cohort study. Participants were recruited from a comprehensive sickle cell clinic in an academic center in the southeastern United States. We included measures validated in an oncology geriatric assessment enriched with additional physical performance measures: usual gait speed, seated grip strength, Timed Up and Go, six-minute walk test, and 30-second chair stand. We also included an additional cognitive measure, which was the Montreal Cognitive Assessment, and additional patient-reported measures at the intersection of sickle cell disease and geriatrics. The primary outcome was the proportion completing the assessment. Secondary outcomes were the proportion consenting, duration of the assessment, acceptability, and adverse events.Eighty percent (44/55) of individuals approached consented, 91% (40/44) completed the SCD-FA in its entirety, and the median duration was 89 min (IQR 80-98). There were no identified adverse events. On the acceptability survey, 95% (38/40) reported the length as appropriate, 2.5% (1/40) reported a question as upsetting, and 5% (2/40) reported portions as difficult. Exploratory analyses of physical function showed 63% (25/40) had a slow usual gait speed (< 1.2 m/s).The SCD-FA is feasible, acceptable, and safe and physical performance tests identified functional impairments in adults with SCD. These findings will inform the next phase of the study where we will assess the validity of the SCD-FA to predict patient-important outcomes in a larger sample of adults with SCD.

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Published In

Pilot and feasibility studies

DOI

EISSN

2055-5784

ISSN

2055-5784

Publication Date

March 2022

Volume

8

Issue

1

Start / End Page

53

Related Subject Headings

  • 4203 Health services and systems
 

Citation

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Chicago
ICMJE
MLA
NLM
Oyedeji, C. I., Hall, K., Luciano, A., Morey, M. C., & Strouse, J. J. (2022). The Sickle Cell Disease Functional Assessment (SCD-FA) tool: a feasibility pilot study. Pilot and Feasibility Studies, 8(1), 53. https://doi.org/10.1186/s40814-022-01005-3
Oyedeji, Charity I., Katherine Hall, Alison Luciano, Miriam C. Morey, and John J. Strouse. “The Sickle Cell Disease Functional Assessment (SCD-FA) tool: a feasibility pilot study.Pilot and Feasibility Studies 8, no. 1 (March 2022): 53. https://doi.org/10.1186/s40814-022-01005-3.
Oyedeji CI, Hall K, Luciano A, Morey MC, Strouse JJ. The Sickle Cell Disease Functional Assessment (SCD-FA) tool: a feasibility pilot study. Pilot and feasibility studies. 2022 Mar;8(1):53.
Oyedeji, Charity I., et al. “The Sickle Cell Disease Functional Assessment (SCD-FA) tool: a feasibility pilot study.Pilot and Feasibility Studies, vol. 8, no. 1, Mar. 2022, p. 53. Epmc, doi:10.1186/s40814-022-01005-3.
Oyedeji CI, Hall K, Luciano A, Morey MC, Strouse JJ. The Sickle Cell Disease Functional Assessment (SCD-FA) tool: a feasibility pilot study. Pilot and feasibility studies. 2022 Mar;8(1):53.
Journal cover image

Published In

Pilot and feasibility studies

DOI

EISSN

2055-5784

ISSN

2055-5784

Publication Date

March 2022

Volume

8

Issue

1

Start / End Page

53

Related Subject Headings

  • 4203 Health services and systems