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The association of improvement in left ventricular ejection fraction with outcomes in patients with heart failure with reduced ejection fraction: data from CHAMP-HF.

Publication ,  Journal Article
DeVore, AD; Hellkamp, AS; Thomas, L; Albert, NM; Butler, J; Patterson, JH; Spertus, JA; Williams, FB; Shen, X; Hernandez, AF; Fonarow, GC
Published in: Eur J Heart Fail
May 2022

AIMS: We assessed for an association between improvements in left ventricular ejection fraction (LVEF) and future outcomes, including health status, in routine clinical practice. METHODS AND RESULTS: CHAMP-HF was a registry of outpatients with heart failure (HF) and LVEF ≤40%. Enrolled participants completed the Kansas City Cardiomyopathy Questionnaire-12 (KCCQ-12) at regular intervals and were followed as part of routine care. We assessed for associations between improvements in LVEF (≥10%) over time and concurrent changes in KCCQ-12, as well as the subsequent risk of poor outcomes. We included 2092 participants in the study. They had the following characteristics: median age 67 years (25th-75th percentile 58-75), 29% female, median duration of HF 2.7 years (0.6-6.8), and median baseline LVEF 30% (23-35). Of the study participants, 689 (33%) had a ≥10% absolute improvement in LVEF. Participants with an LVEF improvement also had an improvement in KCCQ-12 overall summary score compared with participants without an LVEF improvement (+7.6 vs. +3.5, adjusted effect estimate +4.01 [95% confidence interval CI 2.3-5.7]). Similarly, subsequent all-cause death or HF hospitalization occurred in 12% in the LVEF improvement group versus 25% in the group without an LVEF improvement (adjusted hazard ratio 0.50, 95% confidence interval 0.41-0.61). CONCLUSION: In a large cohort of outpatients with chronic HF, improvements in LVEF were associated with improved health status and a reduced risk for future clinical events. These data underscore the importance of improvement in LVEF as a treatment target for medical interventions for patients with chronic HF.

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Published In

Eur J Heart Fail

DOI

EISSN

1879-0844

Publication Date

May 2022

Volume

24

Issue

5

Start / End Page

762 / 770

Location

England

Related Subject Headings

  • Ventricular Function, Left
  • Stroke Volume
  • Male
  • Humans
  • Hospitalization
  • Heart Failure
  • Health Status
  • Female
  • Chronic Disease
  • Cardiovascular System & Hematology
 

Citation

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DeVore, A. D., Hellkamp, A. S., Thomas, L., Albert, N. M., Butler, J., Patterson, J. H., … Fonarow, G. C. (2022). The association of improvement in left ventricular ejection fraction with outcomes in patients with heart failure with reduced ejection fraction: data from CHAMP-HF. Eur J Heart Fail, 24(5), 762–770. https://doi.org/10.1002/ejhf.2486
DeVore, Adam D., Anne S. Hellkamp, Laine Thomas, Nancy M. Albert, Javed Butler, J Herbert Patterson, John A. Spertus, et al. “The association of improvement in left ventricular ejection fraction with outcomes in patients with heart failure with reduced ejection fraction: data from CHAMP-HF.Eur J Heart Fail 24, no. 5 (May 2022): 762–70. https://doi.org/10.1002/ejhf.2486.
DeVore AD, Hellkamp AS, Thomas L, Albert NM, Butler J, Patterson JH, et al. The association of improvement in left ventricular ejection fraction with outcomes in patients with heart failure with reduced ejection fraction: data from CHAMP-HF. Eur J Heart Fail. 2022 May;24(5):762–70.
DeVore, Adam D., et al. “The association of improvement in left ventricular ejection fraction with outcomes in patients with heart failure with reduced ejection fraction: data from CHAMP-HF.Eur J Heart Fail, vol. 24, no. 5, May 2022, pp. 762–70. Pubmed, doi:10.1002/ejhf.2486.
DeVore AD, Hellkamp AS, Thomas L, Albert NM, Butler J, Patterson JH, Spertus JA, Williams FB, Shen X, Hernandez AF, Fonarow GC. The association of improvement in left ventricular ejection fraction with outcomes in patients with heart failure with reduced ejection fraction: data from CHAMP-HF. Eur J Heart Fail. 2022 May;24(5):762–770.
Journal cover image

Published In

Eur J Heart Fail

DOI

EISSN

1879-0844

Publication Date

May 2022

Volume

24

Issue

5

Start / End Page

762 / 770

Location

England

Related Subject Headings

  • Ventricular Function, Left
  • Stroke Volume
  • Male
  • Humans
  • Hospitalization
  • Heart Failure
  • Health Status
  • Female
  • Chronic Disease
  • Cardiovascular System & Hematology