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Association Between Muscle Mass Determined by D3 -Creatine Dilution and Incident Fractures in a Prospective Cohort Study of Older Men.

Publication ,  Journal Article
Cawthon, PM; Peters, KE; Cummings, SR; Orwoll, ES; Hoffman, AR; Ensrud, KE; Cauley, JA; Evans, WJ ...
Published in: J Bone Miner Res
July 2022

The relation between a novel measure of total skeletal muscle mass (assessed by D3 -creatine dilution [D3 Cr]) and incident fracture is unknown. In 1363 men (mean age 84.2 years), we determined D3 Cr muscle mass; Fracture Risk Assessment Tool (FRAX) 10-year probability of hip and major osteoporotic (hip, humerus, vertebral, forearm) fracture; and femoral neck bone mineral density (BMD) (by dual-energy X-ray absorptiometry [DXA]). Incident fractures were centrally adjudicated by review of radiology reports over 4.6 years. Correlations adjusted for weight and height were calculated between femoral neck BMD and D3 Cr muscle mass. Across quartiles of D3 Cr muscle mass/weight, proportional hazards models calculated hazard ratios (HRs) for any (n = 180); nonspine (n = 153); major osteoporotic fracture (n = 85); and hip fracture (n = 40) after adjustment for age, femoral neck BMD, recurrent fall history, and FRAX probability. Models were then adjusted to evaluate the mediating influence of physical performance (walking speed, chair stands, and grip strength). D3 Cr muscle mass was weakly correlated with femoral BMD (r = 0.10, p < 0.001). Compared to men in the highest quartile, those in the lowest quartile of D3 Cr muscle mass/weight had an increased risk of any clinical fracture (HR 1.8; 95% confidence interval [CI], 1.1-2.8); nonspine fracture (HR 1.8; 95% CI, 1.1-3.0), major osteoporotic fracture (HR 2.3; 95% CI, 1.2-4.6), and hip fracture (HR 5.9; 95% CI, 1.6-21.1). Results were attenuated after adjustment for physical performance, but associations remained borderline significant for hip and major osteoporotic fractures (p ≥ 0.05 to 0.10). Low D3 Cr muscle mass/weight is associated with a markedly high risk of hip and potentially other fractures in older men; this association is partially mediated by physical performance. © 2022 American Society for Bone and Mineral Research (ASBMR).

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Published In

J Bone Miner Res

DOI

EISSN

1523-4681

Publication Date

July 2022

Volume

37

Issue

7

Start / End Page

1213 / 1220

Location

United States

Related Subject Headings

  • Risk Factors
  • Risk Assessment
  • Prospective Studies
  • Osteoporotic Fractures
  • Muscles
  • Male
  • Humans
  • Hip Fractures
  • Creatine
  • Bone Density
 

Citation

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Cawthon, P. M., Peters, K. E., Cummings, S. R., Orwoll, E. S., Hoffman, A. R., Ensrud, K. E., … Osteoporotic Fractures in Men (MrOS) Study Research Group, . (2022). Association Between Muscle Mass Determined by D3 -Creatine Dilution and Incident Fractures in a Prospective Cohort Study of Older Men. J Bone Miner Res, 37(7), 1213–1220. https://doi.org/10.1002/jbmr.4505
Cawthon, Peggy M., Katherine E. Peters, Steven R. Cummings, Eric S. Orwoll, Andrew R. Hoffman, Kristine E. Ensrud, Jane A. Cauley, William J. Evans, and William J. Osteoporotic Fractures in Men (MrOS) Study Research Group. “Association Between Muscle Mass Determined by D3 -Creatine Dilution and Incident Fractures in a Prospective Cohort Study of Older Men.J Bone Miner Res 37, no. 7 (July 2022): 1213–20. https://doi.org/10.1002/jbmr.4505.
Cawthon PM, Peters KE, Cummings SR, Orwoll ES, Hoffman AR, Ensrud KE, et al. Association Between Muscle Mass Determined by D3 -Creatine Dilution and Incident Fractures in a Prospective Cohort Study of Older Men. J Bone Miner Res. 2022 Jul;37(7):1213–20.
Cawthon, Peggy M., et al. “Association Between Muscle Mass Determined by D3 -Creatine Dilution and Incident Fractures in a Prospective Cohort Study of Older Men.J Bone Miner Res, vol. 37, no. 7, July 2022, pp. 1213–20. Pubmed, doi:10.1002/jbmr.4505.
Cawthon PM, Peters KE, Cummings SR, Orwoll ES, Hoffman AR, Ensrud KE, Cauley JA, Evans WJ, Osteoporotic Fractures in Men (MrOS) Study Research Group. Association Between Muscle Mass Determined by D3 -Creatine Dilution and Incident Fractures in a Prospective Cohort Study of Older Men. J Bone Miner Res. 2022 Jul;37(7):1213–1220.
Journal cover image

Published In

J Bone Miner Res

DOI

EISSN

1523-4681

Publication Date

July 2022

Volume

37

Issue

7

Start / End Page

1213 / 1220

Location

United States

Related Subject Headings

  • Risk Factors
  • Risk Assessment
  • Prospective Studies
  • Osteoporotic Fractures
  • Muscles
  • Male
  • Humans
  • Hip Fractures
  • Creatine
  • Bone Density