
Navigating the ventricles: Novel insights into the pathogenesis of hydrocephalus.
Congenital hydrocephalus occurs in one in 500-1000 babies born in the United States and acquired hydrocephalus may occur as the consequence of stroke, intraventricular and subarachnoid hemorrhage, traumatic brain injuries, brain tumors, craniectomy or may be idiopathic, as in the case of normal pressure hydrocephalus. Irrespective of its prevalence and significant impact on quality of life, neurosurgeons still rely on invasive cerebrospinal fluid shunt systems for the treatment of hydrocephalus that are exceptionally prone to failure and/or infection. Further understanding of this process at a molecular level, therefore, may have profound implications for improving treatment and quality of life for millions of individuals worldwide. The purpose of this article is to review the current research landscape on hydrocephalus with a focus on recent advances in our understanding of cerebrospinal fluid pathways from an evolutionary, genetics and molecular perspective.
Duke Scholars
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Related Subject Headings
- Subarachnoid Hemorrhage
- Quality of Life
- Infant
- Hydrocephalus
- Humans
- Heart Ventricles
- 4202 Epidemiology
- 3202 Clinical sciences
- 1117 Public Health and Health Services
- 1103 Clinical Sciences
Citation

Published In
DOI
EISSN
Publication Date
Volume
Start / End Page
Location
Related Subject Headings
- Subarachnoid Hemorrhage
- Quality of Life
- Infant
- Hydrocephalus
- Humans
- Heart Ventricles
- 4202 Epidemiology
- 3202 Clinical sciences
- 1117 Public Health and Health Services
- 1103 Clinical Sciences