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Navigating the ventricles: Novel insights into the pathogenesis of hydrocephalus.

Publication ,  Journal Article
Bramall, AN; Anton, ES; Kahle, KT; Fecci, PE
Published in: EBioMedicine
April 2022

Congenital hydrocephalus occurs in one in 500-1000 babies born in the United States and acquired hydrocephalus may occur as the consequence of stroke, intraventricular and subarachnoid hemorrhage, traumatic brain injuries, brain tumors, craniectomy or may be idiopathic, as in the case of normal pressure hydrocephalus. Irrespective of its prevalence and significant impact on quality of life, neurosurgeons still rely on invasive cerebrospinal fluid shunt systems for the treatment of hydrocephalus that are exceptionally prone to failure and/or infection. Further understanding of this process at a molecular level, therefore, may have profound implications for improving treatment and quality of life for millions of individuals worldwide. The purpose of this article is to review the current research landscape on hydrocephalus with a focus on recent advances in our understanding of cerebrospinal fluid pathways from an evolutionary, genetics and molecular perspective.

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Published In

EBioMedicine

DOI

EISSN

2352-3964

Publication Date

April 2022

Volume

78

Start / End Page

103931

Location

Netherlands

Related Subject Headings

  • Subarachnoid Hemorrhage
  • Quality of Life
  • Infant
  • Hydrocephalus
  • Humans
  • Heart Ventricles
  • 4202 Epidemiology
  • 3202 Clinical sciences
  • 1117 Public Health and Health Services
  • 1103 Clinical Sciences
 

Citation

APA
Chicago
ICMJE
MLA
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Bramall, A. N., Anton, E. S., Kahle, K. T., & Fecci, P. E. (2022). Navigating the ventricles: Novel insights into the pathogenesis of hydrocephalus. EBioMedicine, 78, 103931. https://doi.org/10.1016/j.ebiom.2022.103931
Bramall, Alexa N., E. S. Anton, Kristopher T. Kahle, and Peter E. Fecci. “Navigating the ventricles: Novel insights into the pathogenesis of hydrocephalus.EBioMedicine 78 (April 2022): 103931. https://doi.org/10.1016/j.ebiom.2022.103931.
Bramall AN, Anton ES, Kahle KT, Fecci PE. Navigating the ventricles: Novel insights into the pathogenesis of hydrocephalus. EBioMedicine. 2022 Apr;78:103931.
Bramall, Alexa N., et al. “Navigating the ventricles: Novel insights into the pathogenesis of hydrocephalus.EBioMedicine, vol. 78, Apr. 2022, p. 103931. Pubmed, doi:10.1016/j.ebiom.2022.103931.
Bramall AN, Anton ES, Kahle KT, Fecci PE. Navigating the ventricles: Novel insights into the pathogenesis of hydrocephalus. EBioMedicine. 2022 Apr;78:103931.
Journal cover image

Published In

EBioMedicine

DOI

EISSN

2352-3964

Publication Date

April 2022

Volume

78

Start / End Page

103931

Location

Netherlands

Related Subject Headings

  • Subarachnoid Hemorrhage
  • Quality of Life
  • Infant
  • Hydrocephalus
  • Humans
  • Heart Ventricles
  • 4202 Epidemiology
  • 3202 Clinical sciences
  • 1117 Public Health and Health Services
  • 1103 Clinical Sciences