Overview
As an assistant professor of neurosurgery working in adult hydrocephalus, my research focuses on cerebrospinal fluid (CSF) pathways in the brain and the mechanisms by which hydrocephalus develops. In addition to intersecting every area of neurosurgery from pediatrics to trauma, abnormalities in CSF physiology have been implicated in a multitude of neurological diseases, from Alzheimer’s disease to depression.
My basic science research involves identifying the mechanisms of intracranial pressure regulation by choroid plexus epithelial cells. The lab uses genetic mouse models to explore important genes and/or proteins involved in CSF regulation. Our goal is to develop novel, long lasting and minimally invasive strategies to diagnose and treat CSF flow disorders.
Current Appointments & Affiliations
Recent Publications
Journal Article
EBioMedicine
·
April 2022
Congenital hydrocephalus occurs in one in 500-1000 babies born in the United States and acquired hydrocephalus may occur as the consequence of stroke, intraventricular and subarachnoid hemorrhage, traumatic brain injuries, brain tumors, craniectomy or may ...
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Journal Article
Expert Rev Clin Pharmacol
·
October 2020
INTRODUCTION: Despite maximal surgical resection and chemoradiation, glioblastoma (GBM) continues to be associated with significant morbidity and mortality. Novel therapeutic strategies are urgently needed. Given success in treating multiple other forms of ...
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Journal Article
J Neurooncol
·
September 2018
BACKGROUND: Although the majority of current medulloblastoma adjuvant therapy protocols treat patients with ≥ 1.5 cm2 residual tumor as high risk with increased craniospinal irradiation, the true prognostic significance of extent of resection (EOR) in medu ...
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Education, Training & Certifications
University of Toronto (Canada) ·
2015
M.D.
University of Toronto (Canada) ·
2010
Ph.D.
