Overview
As an assistant professor of neurosurgery working in adult hydrocephalus, my research focuses on cerebrospinal fluid (CSF) pathways in the brain and the mechanisms by which hydrocephalus develops. In addition to intersecting every area of neurosurgery from pediatrics to trauma, abnormalities in CSF physiology have been implicated in a multitude of neurological diseases, from Alzheimer’s disease to depression.
My basic science research involves identifying the mechanisms of intracranial pressure regulation by choroid plexus epithelial cells. The lab uses genetic mouse models to explore important genes and/or proteins involved in CSF regulation. Our goal is to develop novel, long lasting and minimally invasive strategies to diagnose and treat CSF flow disorders.
Current Appointments & Affiliations
Recent Publications
Adapting Laser Interstitial Thermal Therapy for the Treatment of Naturally Occurring Intracranial Tumors in Dogs.
Journal Article Clin Cancer Res · October 15, 2025 PURPOSE: Laser interstitial thermal therapy (LITT) is a minimally invasive surgical intervention permitting thermal ablation of intracranial targets such as tumors, radiation necrosis, or epileptogenic brain, including lesions that are deep, difficult to a ... Full text Link to item CiteCorrelation between lumbar puncture opening pressure and venous sinus pressure gradient in idiopathic intracranial hypertension (IIH).
Journal Article Interv Neuroradiol · April 24, 2025 BackgroundVenous hypertension has become a recognized condition associated with idiopathic intracranial hypertension (IIH). Thresholds for dural venous sinus stenting (VSS) remain a topic of debate.MethodsIn 50 IIH patients, the lumbar puncture opening pre ... Full text Link to item CiteNavigating the ventricles: Novel insights into the pathogenesis of hydrocephalus.
Journal Article EBioMedicine · April 2022 Congenital hydrocephalus occurs in one in 500-1000 babies born in the United States and acquired hydrocephalus may occur as the consequence of stroke, intraventricular and subarachnoid hemorrhage, traumatic brain injuries, brain tumors, craniectomy or may ... Full text Link to item CiteRecent Grants
TA Phase IV Placebo-controlled Single Center Trial for Tirzepatide in Idiopathic Intracranial Hypertension Trial (TIIHT)," protocol I8F-NS-I004
Clinical TrialPrincipal Investigator · Awarded by Lilly USA, LLC · 2025 - 2033Medical Scientist Training Program
Inst. Training Prgm or CMEPreceptor · Awarded by National Institute of General Medical Sciences · 2022 - 2027View All Grants