Journal ArticleInterv Neuroradiol · April 24, 2025
BackgroundVenous hypertension has become a recognized condition associated with idiopathic intracranial hypertension (IIH). Thresholds for dural venous sinus stenting (VSS) remain a topic of debate.MethodsIn 50 IIH patients, the lumbar puncture opening pre ...
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Journal ArticleEBioMedicine · April 2022
Congenital hydrocephalus occurs in one in 500-1000 babies born in the United States and acquired hydrocephalus may occur as the consequence of stroke, intraventricular and subarachnoid hemorrhage, traumatic brain injuries, brain tumors, craniectomy or may ...
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Journal ArticleExpert Rev Clin Pharmacol · October 2020
INTRODUCTION: Despite maximal surgical resection and chemoradiation, glioblastoma (GBM) continues to be associated with significant morbidity and mortality. Novel therapeutic strategies are urgently needed. Given success in treating multiple other forms of ...
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Journal ArticleJ Neurooncol · September 2018
BACKGROUND: Although the majority of current medulloblastoma adjuvant therapy protocols treat patients with ≥ 1.5 cm2 residual tumor as high risk with increased craniospinal irradiation, the true prognostic significance of extent of resection (EOR) in medu ...
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Chapter · April 24, 2018
Patients with glioblastoma (GBM) have a dismal prognosis despite the most aggressive multimodal regimen affording a median survival of barely 15 months. Thus, the field is in desperate need of therapies that specifically and safely target these tumors. Arm ...
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Chapter · January 1, 2018
To achieve optimal patient outcomes in brain tumor surgery, it is critical to know how to identify, manage and prevent common complications. From specific to broad, complications can be categorized as local, regional, or systemic. Local complications depen ...
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Journal ArticleJournal of Bionanoscience · August 1, 2016
Malignant gliomas are rapidly growing and invasive brain tumors that are refractory to treatment with surgery, chemotherapy, and radiation. Unlike solid tumors in other organs of the body, brain tumors remain uniquely difficult to identify and treat due to ...
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Journal ArticleBMJ Case Rep · February 25, 2016
The Finetech-Brindley sacral anterior root stimulator (SARS) is implanted for the treatment of bladder dysfunction following spinal cord injury (SCI) and has been successful in improving micturition in many patients with SCI. This case describes a 62-year- ...
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Journal ArticleDev Cell · January 12, 2015
Ankrd11 is a potential chromatin regulator implicated in neural development and autism spectrum disorder (ASD) with no known function in the brain. Here, we show that knockdown of Ankrd11 in developing murine or human cortical neural precursors caused decr ...
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Journal ArticleJ Surg Educ · 2015
OBJECTIVE: Surgical trainees are often subject to the negative consequences of medical error, and it is therefore important to determine how trainees cope with error and to find ways of supporting trainees when catastrophic events occur. This article exami ...
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Journal ArticleProc Natl Acad Sci U S A · December 30, 2014
Inherited photoreceptor degenerations (IPDs), a group of incurable progressive blinding diseases, are caused by mutations in more than 200 genes, but little is known about the molecular pathogenesis of photoreceptor (PR) death. Increased retinal expression ...
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Journal ArticleWorld Neurosurg · November 2014
OBJECTIVE: To adapt a study exploring the needs of neurosurgery patients in a tertiary care hospital in Canada to examine, for the first time, the perspectives of neurosurgery patients in a low-income country with limited health care resources. METHODS: Se ...
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Journal ArticleCan J Neurol Sci · January 2014
BACKGROUND: Patients confronted with the daunting prospect of a potentially life-altering procedure with uncertain outcome demonstrate high levels of anxiety and need for information. Regardless, many patients are left unsatisfied by the amount of informat ...
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Journal ArticleJ Clin Invest · June 2013
To explore the physiological functions of endothelin-2 (ET-2), we generated gene-targeted mouse models. Global Et2 knockout mice exhibited severe growth retardation and juvenile lethality. Despite normal milk intake, they suffered from internal starvation ...
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Journal ArticlePLoS One · 2013
Expression of the Endothelin-2 (Edn2) mRNA is greatly increased in the photoreceptors (PRs) of mouse models of inherited PR degeneration (IPD). To examine the role of Edn2 in mutant PR survival, we generated Edn2(-/-) mice carrying homozygous Pde6b(rd1) al ...
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Journal ArticleHum Mol Genet · January 15, 2011
The role of oxidative stress within photoreceptors (PRs) in inherited photoreceptor degeneration (IPD) is unclear. We investigated this question using four IPD mouse models (Pde6b(rd1/rd1), Pde6b(atrd1/atrd1), Rho(-/-) and Prph2(rds/rds)) and compared the ...
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Journal ArticleAnnu Rev Neurosci · 2010
The association of more than 140 genes with human photoreceptor degenerations, together with studies of animal models of these monogenic diseases, has provided great insight into their pathogenesis. Here we review the responses of the retina to photorecept ...
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