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The physiological and pathophysiological roles of the autophagy lysosomal system in the conventional aqueous humor outflow pathway: More than cellular clean up.

Publication ,  Journal Article
Shim, MS; Liton, PB
Published in: Prog Retin Eye Res
September 2022

During the last few years, the autophagy lysosomal system is emerging as a central cellular pathway with roles in survival, acting as a housekeeper and stress response mechanism. Studies by our and other labs suggest that autophagy might play an essential role in maintaining aqueous humor outflow homeostasis, and that malfunction of autophagy in outflow pathway cells might predispose to ocular hypertension and glaucoma pathogenesis. In this review, we will collect the current knowledge and discuss the molecular mechanisms by which autophagy does or might regulate normal outflow pathway tissue function, and its response to different types of stressors (oxidative stress and mechanical stress). We will also discuss novel roles of autophagy and lysosomal enzymes in modulation of TGFβ signaling and ECM remodeling, and the link between dysregulated autophagy and cellular senescence. We will examine what we have learnt, using pre-clinical animal models about how dysregulated autophagy can contribute to disease and apply that to the current status of autophagy in human glaucoma. Finally, we will consider and discuss the challenges and the potential of autophagy as a therapeutic target for the treatment of ocular hypertension and glaucoma.

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Published In

Prog Retin Eye Res

DOI

EISSN

1873-1635

Publication Date

September 2022

Volume

90

Start / End Page

101064

Location

England

Related Subject Headings

  • Trabecular Meshwork
  • Ophthalmology & Optometry
  • Lysosomes
  • Intraocular Pressure
  • Humans
  • Glaucoma
  • Autophagy
  • Aqueous Humor
  • Animals
  • 3212 Ophthalmology and optometry
 

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Journal cover image

Published In

Prog Retin Eye Res

DOI

EISSN

1873-1635

Publication Date

September 2022

Volume

90

Start / End Page

101064

Location

England

Related Subject Headings

  • Trabecular Meshwork
  • Ophthalmology & Optometry
  • Lysosomes
  • Intraocular Pressure
  • Humans
  • Glaucoma
  • Autophagy
  • Aqueous Humor
  • Animals
  • 3212 Ophthalmology and optometry