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Plasmonic Fluorescence Enhancement in Diagnostics for Clinical Tests at Point-of-Care: A Review of Recent Technologies.

Publication ,  Journal Article
Semeniak, D; Cruz, DF; Chilkoti, A; Mikkelsen, MH
Published in: Advanced materials (Deerfield Beach, Fla.)
August 2023

Fluorescence-based biosensors have widely been used in the life-sciences and biomedical applications due to their low limit of detection and a diverse selection of fluorophores that enable simultaneous measurements of multiple biomarkers. Recent research effort has been made to implement fluorescent biosensors into the exploding field of point-of-care testing (POCT), which uses cost-effective strategies for rapid and affordable diagnostic testing. However, fluorescence-based assays often suffer from their feeble signal at low analyte concentrations, which often requires sophisticated, costly, and bulky instrumentation to maintain high detection sensitivity. Metal- and metal oxide-based nanostructures offer a simple solution to increase the output signal from fluorescent biosensors due to the generation of high field enhancements close to a metal or metal oxide surface, which has been shown to improve the excitation rate, quantum yield, photostability, and radiation pattern of fluorophores. This article provides an overview of existing biosensors that employ various strategies for fluorescence enhancement via nanostructures and have demonstrated the potential for use as POCT. Biosensors using nanostructures such as planar substrates, freestanding nanoparticles, and metal-dielectric-metal nanocavities are discussed with an emphasis placed on technologies that have shown promise towards POCT applications without the need for centralized laboratories.

Duke Scholars

Published In

Advanced materials (Deerfield Beach, Fla.)

DOI

EISSN

1521-4095

ISSN

0935-9648

Publication Date

August 2023

Volume

35

Issue

34

Start / End Page

e2107986

Related Subject Headings

  • Point-of-Care Systems
  • Oxides
  • Nanostructures
  • Nanoscience & Nanotechnology
  • Metals
  • Fluorescent Dyes
  • Biosensing Techniques
  • 51 Physical sciences
  • 40 Engineering
  • 34 Chemical sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Semeniak, D., Cruz, D. F., Chilkoti, A., & Mikkelsen, M. H. (2023). Plasmonic Fluorescence Enhancement in Diagnostics for Clinical Tests at Point-of-Care: A Review of Recent Technologies. Advanced Materials (Deerfield Beach, Fla.), 35(34), e2107986. https://doi.org/10.1002/adma.202107986
Semeniak, Daria, Daniela F. Cruz, Ashutosh Chilkoti, and Maiken H. Mikkelsen. “Plasmonic Fluorescence Enhancement in Diagnostics for Clinical Tests at Point-of-Care: A Review of Recent Technologies.Advanced Materials (Deerfield Beach, Fla.) 35, no. 34 (August 2023): e2107986. https://doi.org/10.1002/adma.202107986.
Semeniak D, Cruz DF, Chilkoti A, Mikkelsen MH. Plasmonic Fluorescence Enhancement in Diagnostics for Clinical Tests at Point-of-Care: A Review of Recent Technologies. Advanced materials (Deerfield Beach, Fla). 2023 Aug;35(34):e2107986.
Semeniak, Daria, et al. “Plasmonic Fluorescence Enhancement in Diagnostics for Clinical Tests at Point-of-Care: A Review of Recent Technologies.Advanced Materials (Deerfield Beach, Fla.), vol. 35, no. 34, Aug. 2023, p. e2107986. Epmc, doi:10.1002/adma.202107986.
Semeniak D, Cruz DF, Chilkoti A, Mikkelsen MH. Plasmonic Fluorescence Enhancement in Diagnostics for Clinical Tests at Point-of-Care: A Review of Recent Technologies. Advanced materials (Deerfield Beach, Fla). 2023 Aug;35(34):e2107986.
Journal cover image

Published In

Advanced materials (Deerfield Beach, Fla.)

DOI

EISSN

1521-4095

ISSN

0935-9648

Publication Date

August 2023

Volume

35

Issue

34

Start / End Page

e2107986

Related Subject Headings

  • Point-of-Care Systems
  • Oxides
  • Nanostructures
  • Nanoscience & Nanotechnology
  • Metals
  • Fluorescent Dyes
  • Biosensing Techniques
  • 51 Physical sciences
  • 40 Engineering
  • 34 Chemical sciences