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Clinical research in dementia: A perspective on implementing innovation.

Publication ,  Journal Article
Boccardi, M; Handels, R; Gold, M; Grazia, A; Lutz, MW; Martin, M; Nosheny, R; Robillard, JM; Weidner, W; Alexandersson, J; Thyrian, JR ...
Published in: Alzheimers Dement
November 2022

The increasing global prevalence of dementia demands concrete actions that are aimed strategically at optimizing processes that drive clinical innovation. The first step in this direction requires outlining hurdles in the transition from research to practice. The different parties needed to support translational processes have communication mismatches; methodological gaps hamper evidence-based decision-making; and data are insufficient to provide reliable estimates of long-term health benefits and costs in decisional models. Pilot projects are tackling some of these gaps, but appropriate methods often still need to be devised or adapted to the dementia field. A consistent implementation perspective along the whole translational continuum, explicitly defined and shared among the relevant stakeholders, should overcome the "research-versus-adoption" dichotomy, and tackle the implementation cliff early on. Concrete next steps may consist of providing tools that support the effective participation of heterogeneous stakeholders and agreeing on a definition of clinical significance that facilitates the selection of proper outcome measures.

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Published In

Alzheimers Dement

DOI

EISSN

1552-5279

Publication Date

November 2022

Volume

18

Issue

11

Start / End Page

2352 / 2367

Location

United States

Related Subject Headings

  • Pilot Projects
  • Outcome Assessment, Health Care
  • Humans
  • Geriatrics
  • Dementia
  • Communication
  • 5202 Biological psychology
  • 3209 Neurosciences
  • 3202 Clinical sciences
  • 1109 Neurosciences
 

Citation

APA
Chicago
ICMJE
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Boccardi, M., Handels, R., Gold, M., Grazia, A., Lutz, M. W., Martin, M., … Teipel, S. (2022). Clinical research in dementia: A perspective on implementing innovation. Alzheimers Dement, 18(11), 2352–2367. https://doi.org/10.1002/alz.12622
Boccardi, Marina, Ron Handels, Michael Gold, Alice Grazia, Michael W. Lutz, Mike Martin, Rachel Nosheny, et al. “Clinical research in dementia: A perspective on implementing innovation.Alzheimers Dement 18, no. 11 (November 2022): 2352–67. https://doi.org/10.1002/alz.12622.
Boccardi M, Handels R, Gold M, Grazia A, Lutz MW, Martin M, et al. Clinical research in dementia: A perspective on implementing innovation. Alzheimers Dement. 2022 Nov;18(11):2352–67.
Boccardi, Marina, et al. “Clinical research in dementia: A perspective on implementing innovation.Alzheimers Dement, vol. 18, no. 11, Nov. 2022, pp. 2352–67. Pubmed, doi:10.1002/alz.12622.
Boccardi M, Handels R, Gold M, Grazia A, Lutz MW, Martin M, Nosheny R, Robillard JM, Weidner W, Alexandersson J, Thyrian JR, Winblad B, Barbarino P, Khachaturian AS, Teipel S. Clinical research in dementia: A perspective on implementing innovation. Alzheimers Dement. 2022 Nov;18(11):2352–2367.
Journal cover image

Published In

Alzheimers Dement

DOI

EISSN

1552-5279

Publication Date

November 2022

Volume

18

Issue

11

Start / End Page

2352 / 2367

Location

United States

Related Subject Headings

  • Pilot Projects
  • Outcome Assessment, Health Care
  • Humans
  • Geriatrics
  • Dementia
  • Communication
  • 5202 Biological psychology
  • 3209 Neurosciences
  • 3202 Clinical sciences
  • 1109 Neurosciences