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SABRE enhancement with oscillating pulse sequences.

Publication ,  Journal Article
Li, X; Lindale, JR; Eriksson, SL; Warren, WS
Published in: Physical chemistry chemical physics : PCCP
July 2022

SABRE (Signal Amplification by Reversible Exchange) methods provide a simple, fast, and cost-effective method to hyperpolarize a wide variety of molecules in solution, and have been demonstrated with protons and, more recently, with heteronuclei (X-SABRE). Here, we present several oscillating pulse sequences that use magnetic fields far away from the resonance condition of continuous excitation and can commonly triple the polarization. An analysis with average Hamiltonian theory indicates that the oscillating pulse, in effect, adjusts the J-couplings between hydrides and target nuclei and that a much weaker coupling produces maximum polarization. This theoretical treatment, combined with simulations and experiment, shows substantial magnetization improvements relative to traditional X-SABRE methods. It also shows that, in contrast to most pulse sequence applications, waveforms with reduced time symmetry in the toggling frame make magnetization generation more robust to experimental imperfections.

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Published In

Physical chemistry chemical physics : PCCP

DOI

EISSN

1463-9084

ISSN

1463-9076

Publication Date

July 2022

Volume

24

Issue

27

Start / End Page

16462 / 16470

Related Subject Headings

  • Protons
  • Magnetic Resonance Spectroscopy
  • Magnetic Fields
  • Hydrogen
  • Chemical Physics
  • Catalysis
  • 51 Physical sciences
  • 40 Engineering
  • 34 Chemical sciences
  • 09 Engineering
 

Citation

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Li, X., Lindale, J. R., Eriksson, S. L., & Warren, W. S. (2022). SABRE enhancement with oscillating pulse sequences. Physical Chemistry Chemical Physics : PCCP, 24(27), 16462–16470. https://doi.org/10.1039/d2cp00899h
Li, Xiaoqing, Jacob R. Lindale, Shannon L. Eriksson, and Warren S. Warren. “SABRE enhancement with oscillating pulse sequences.Physical Chemistry Chemical Physics : PCCP 24, no. 27 (July 2022): 16462–70. https://doi.org/10.1039/d2cp00899h.
Li X, Lindale JR, Eriksson SL, Warren WS. SABRE enhancement with oscillating pulse sequences. Physical chemistry chemical physics : PCCP. 2022 Jul;24(27):16462–70.
Li, Xiaoqing, et al. “SABRE enhancement with oscillating pulse sequences.Physical Chemistry Chemical Physics : PCCP, vol. 24, no. 27, July 2022, pp. 16462–70. Epmc, doi:10.1039/d2cp00899h.
Li X, Lindale JR, Eriksson SL, Warren WS. SABRE enhancement with oscillating pulse sequences. Physical chemistry chemical physics : PCCP. 2022 Jul;24(27):16462–16470.
Journal cover image

Published In

Physical chemistry chemical physics : PCCP

DOI

EISSN

1463-9084

ISSN

1463-9076

Publication Date

July 2022

Volume

24

Issue

27

Start / End Page

16462 / 16470

Related Subject Headings

  • Protons
  • Magnetic Resonance Spectroscopy
  • Magnetic Fields
  • Hydrogen
  • Chemical Physics
  • Catalysis
  • 51 Physical sciences
  • 40 Engineering
  • 34 Chemical sciences
  • 09 Engineering