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Origin, specification and differentiation of a rare supporting-like lineage in the developing mouse gonad.

Publication ,  Journal Article
Mayère, C; Regard, V; Perea-Gomez, A; Bunce, C; Neirijnck, Y; Djari, C; Bellido-Carreras, N; Sararols, P; Reeves, R; Greenaway, S; Simon, M ...
Published in: Sci Adv
May 27, 2022

Gonadal sex determination represents a unique model for studying cell fate decisions. However, a complete understanding of the different cell lineages forming the developing testis and ovary remains elusive. Here, we investigated the origin, specification, and subsequent sex-specific differentiation of a previously uncharacterized population of supporting-like cells (SLCs) in the developing mouse gonads. The SLC lineage is closely related to the coelomic epithelium and specified as early as E10.5, making it the first somatic lineage to be specified in the bipotential gonad. SLC progenitors are localized within the genital ridge at the interface with the mesonephros and initially coexpress Wnt4 and Sox9. SLCs become sexually dimorphic around E12.5, progressively acquire a more Sertoli- or pregranulosa-like identity and contribute to the formation of the rete testis and rete ovarii. Last, we found that WNT4 is a crucial regulator of the SLC lineage and is required for normal development of the rete testis.

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Published In

Sci Adv

DOI

EISSN

2375-2548

Publication Date

May 27, 2022

Volume

8

Issue

21

Start / End Page

eabm0972

Location

United States
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Mayère, C., Regard, V., Perea-Gomez, A., Bunce, C., Neirijnck, Y., Djari, C., … Nef, S. (2022). Origin, specification and differentiation of a rare supporting-like lineage in the developing mouse gonad. Sci Adv, 8(21), eabm0972. https://doi.org/10.1126/sciadv.abm0972
Mayère, Chloé, Violaine Regard, Aitana Perea-Gomez, Corey Bunce, Yasmine Neirijnck, Cyril Djari, Natividad Bellido-Carreras, et al. “Origin, specification and differentiation of a rare supporting-like lineage in the developing mouse gonad.Sci Adv 8, no. 21 (May 27, 2022): eabm0972. https://doi.org/10.1126/sciadv.abm0972.
Mayère C, Regard V, Perea-Gomez A, Bunce C, Neirijnck Y, Djari C, et al. Origin, specification and differentiation of a rare supporting-like lineage in the developing mouse gonad. Sci Adv. 2022 May 27;8(21):eabm0972.
Mayère, Chloé, et al. “Origin, specification and differentiation of a rare supporting-like lineage in the developing mouse gonad.Sci Adv, vol. 8, no. 21, May 2022, p. eabm0972. Pubmed, doi:10.1126/sciadv.abm0972.
Mayère C, Regard V, Perea-Gomez A, Bunce C, Neirijnck Y, Djari C, Bellido-Carreras N, Sararols P, Reeves R, Greenaway S, Simon M, Siggers P, Condrea D, Kühne F, Gantar I, Tang F, Stévant I, Batti L, Ghyselinck NB, Wilhelm D, Greenfield A, Capel B, Chaboissier M-C, Nef S. Origin, specification and differentiation of a rare supporting-like lineage in the developing mouse gonad. Sci Adv. 2022 May 27;8(21):eabm0972.

Published In

Sci Adv

DOI

EISSN

2375-2548

Publication Date

May 27, 2022

Volume

8

Issue

21

Start / End Page

eabm0972

Location

United States