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Genetics in chronic kidney disease: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference.

Publication ,  Conference
KDIGO Conference Participants,
Published in: Kidney Int
June 2022

Numerous genes for monogenic kidney diseases with classical patterns of inheritance, as well as genes for complex kidney diseases that manifest in combination with environmental factors, have been discovered. Genetic findings are increasingly used to inform clinical management of nephropathies, and have led to improved diagnostics, disease surveillance, choice of therapy, and family counseling. All of these steps rely on accurate interpretation of genetic data, which can be outpaced by current rates of data collection. In March of 2021, Kidney Diseases: Improving Global Outcomes (KDIGO) held a Controversies Conference on "Genetics in Chronic Kidney Disease (CKD)" to review the current state of understanding of monogenic and complex (polygenic) kidney diseases, processes for applying genetic findings in clinical medicine, and use of genomics for defining and stratifying CKD. Given the important contribution of genetic variants to CKD, practitioners with CKD patients are advised to "think genetic," which specifically involves obtaining a family history, collecting detailed information on age of CKD onset, performing clinical examination for extrarenal symptoms, and considering genetic testing. To improve the use of genetics in nephrology, meeting participants advised developing an advanced training or subspecialty track for nephrologists, crafting guidelines for testing and treatment, and educating patients, students, and practitioners. Key areas of future research, including clinical interpretation of genome variation, electronic phenotyping, global representation, kidney-specific molecular data, polygenic scores, translational epidemiology, and open data resources, were also identified.

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Published In

Kidney Int

DOI

EISSN

1523-1755

Publication Date

June 2022

Volume

101

Issue

6

Start / End Page

1126 / 1141

Location

United States

Related Subject Headings

  • Urology & Nephrology
  • Renal Insufficiency, Chronic
  • Nephrology
  • Humans
  • Congresses as Topic
  • 3202 Clinical sciences
  • 1103 Clinical Sciences
 

Citation

APA
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ICMJE
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KDIGO Conference Participants, . (2022). Genetics in chronic kidney disease: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference. In Kidney Int (Vol. 101, pp. 1126–1141). United States. https://doi.org/10.1016/j.kint.2022.03.019
KDIGO Conference Participants, Bei. “Genetics in chronic kidney disease: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference.” In Kidney Int, 101:1126–41, 2022. https://doi.org/10.1016/j.kint.2022.03.019.
KDIGO Conference Participants, Bei. “Genetics in chronic kidney disease: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference.Kidney Int, vol. 101, no. 6, 2022, pp. 1126–41. Pubmed, doi:10.1016/j.kint.2022.03.019.
Journal cover image

Published In

Kidney Int

DOI

EISSN

1523-1755

Publication Date

June 2022

Volume

101

Issue

6

Start / End Page

1126 / 1141

Location

United States

Related Subject Headings

  • Urology & Nephrology
  • Renal Insufficiency, Chronic
  • Nephrology
  • Humans
  • Congresses as Topic
  • 3202 Clinical sciences
  • 1103 Clinical Sciences