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Eight-Fold Intensification of Electrochemical Azidooxygenation with a Flow-Through Electrode

Publication ,  Journal Article
Guo, S; Kim, MJ; Siu, JC; Von Windheim, N; Gall, K; Lin, S; Wiley, BJ
Published in: ACS Sustainable Chemistry and Engineering
June 13, 2022

Finding ways to reduce reactor volume while increasing product output for electro-organic reactions would facilitate the broader adoption of such reactions for the production of chemicals in a commercial setting. This work investigates how the use of flow with different electrode structures impacts the productivity (i.e., the rate of product generation) of a TEMPO-mediated azidooxygenation reaction. Comparison of a flow and batch process with carbon paper (CP) demonstrated a 3.8-fold-higher productivity for the flow reactor. Three custom carbon electrodes, sintered carbon paper (S-CP), carbon nanofiber (CNF), and composite carbon microfiber-nanofiber (MNC), were studied in the flow reactor to evaluate how changing the electrode structure affected productivity. Under the optimum conditions, these electrodes achieved productivities 5.4, 6.5, and 7.8 times higher than the average batch reactor, respectively. Recycling the outlet from the flow reactor with the MNC electrode back into the inlet achieved an 81% yield in 36 min, while the batch reactor obtained a 75% yield in 5 h. These findings demonstrate that the productivity of electro-organic reactions can be substantially improved through the use of novel flow-through electrodes.

Duke Scholars

Published In

ACS Sustainable Chemistry and Engineering

DOI

EISSN

2168-0485

Publication Date

June 13, 2022

Volume

10

Issue

23

Start / End Page

7648 / 7657

Related Subject Headings

  • 4004 Chemical engineering
  • 3401 Analytical chemistry
  • 0904 Chemical Engineering
  • 0502 Environmental Science and Management
  • 0301 Analytical Chemistry
 

Citation

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Guo, S., Kim, M. J., Siu, J. C., Von Windheim, N., Gall, K., Lin, S., & Wiley, B. J. (2022). Eight-Fold Intensification of Electrochemical Azidooxygenation with a Flow-Through Electrode. ACS Sustainable Chemistry and Engineering, 10(23), 7648–7657. https://doi.org/10.1021/acssuschemeng.2c01525
Guo, S., M. J. Kim, J. C. Siu, N. Von Windheim, K. Gall, S. Lin, and B. J. Wiley. “Eight-Fold Intensification of Electrochemical Azidooxygenation with a Flow-Through Electrode.” ACS Sustainable Chemistry and Engineering 10, no. 23 (June 13, 2022): 7648–57. https://doi.org/10.1021/acssuschemeng.2c01525.
Guo S, Kim MJ, Siu JC, Von Windheim N, Gall K, Lin S, et al. Eight-Fold Intensification of Electrochemical Azidooxygenation with a Flow-Through Electrode. ACS Sustainable Chemistry and Engineering. 2022 Jun 13;10(23):7648–57.
Guo, S., et al. “Eight-Fold Intensification of Electrochemical Azidooxygenation with a Flow-Through Electrode.” ACS Sustainable Chemistry and Engineering, vol. 10, no. 23, June 2022, pp. 7648–57. Scopus, doi:10.1021/acssuschemeng.2c01525.
Guo S, Kim MJ, Siu JC, Von Windheim N, Gall K, Lin S, Wiley BJ. Eight-Fold Intensification of Electrochemical Azidooxygenation with a Flow-Through Electrode. ACS Sustainable Chemistry and Engineering. 2022 Jun 13;10(23):7648–7657.
Journal cover image

Published In

ACS Sustainable Chemistry and Engineering

DOI

EISSN

2168-0485

Publication Date

June 13, 2022

Volume

10

Issue

23

Start / End Page

7648 / 7657

Related Subject Headings

  • 4004 Chemical engineering
  • 3401 Analytical chemistry
  • 0904 Chemical Engineering
  • 0502 Environmental Science and Management
  • 0301 Analytical Chemistry