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Residual Inflammatory Risk and its Association With Events in East Asian Patients After Coronary Intervention

Publication ,  Journal Article
Ahn, JH; Tantry, US; Kang, MG; Park, HW; Koh, JS; Bae, JS; Cho, SY; Kim, KH; Jang, JY; Park, JR; Park, Y; Hwang, SJ; Kwak, CH; Hwang, JY ...
Published in: JACC: Asia
June 1, 2022

Background: East Asian population has a low level of inflammation compared with Western population. The prognostic implication of residual inflammatory risk (RIR) remains uncertain in East Asians. Objectives: This study sought to provide an analysis to estimate early-determined RIR and its association with clinical outcomes in East Asian patients with coronary artery disease (CAD). Methods: In an East Asian registry including patients with CAD undergoing percutaneous coronary intervention (PCI) (n = 4,562), RIR status was determined by measuring high-sensitivity C-reactive protein (hsCRP) serially at admission and at 1-month follow-up. Patients were stratified into 4 groups according to hsCRP criteria (≥2 mg/L): 1) persistent low RIR (lowon admission-low1 month: 51.0%); 2) fortified RIR (lowon admission-high 1 month: 10.3%); 3) attenuated RIR (highon admission-low1 month: 20.5%); and 4) persistent high RIR (highon admission-high1 month: 18.3%). The risks of all-cause death, ischemic events, and major bleeding were evaluated. Results: In our cohort, median levels of hsCRP were significantly decreased over time (1.3 to 0.9 mg/L; P < 0.001). Compared with hsCRP on admission, hsCRP at 1 month showed the greater associations with all-cause death and ischemic event. During clinical follow-up, risks of clinical events were significantly different across the groups (log-rank test, P < 0.001). Compared with other RIR groups, persistent high RIR showed the higher risk for all-cause death (HRadjusted, 1.92; 95% CI: 1.44 to 2.55; P < 0.001), ischemic events (HRadjusted, 1.26; 95% CI: 1.02 to 1.56; P = 0.032), and major bleeding (HRadjusted, 1.98; 95% CI: 1.30 to 2.99; P < 0.001), respectively. Conclusions: Approximately one-fifth of East Asian patients with CAD have persistent high RIR, which shows the close association with occurrence of ischemic and bleeding events. (Gyeongsang National University Hospital Registry [GNUH]; NCT04650529)

Duke Scholars

Published In

JACC: Asia

DOI

EISSN

2772-3747

Publication Date

June 1, 2022

Volume

2

Issue

3P2

Start / End Page

323 / 337
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Ahn, J. H., Tantry, U. S., Kang, M. G., Park, H. W., Koh, J. S., Bae, J. S., … Jeong, Y. H. (2022). Residual Inflammatory Risk and its Association With Events in East Asian Patients After Coronary Intervention. JACC: Asia, 2(3P2), 323–337. https://doi.org/10.1016/j.jacasi.2021.11.014

Published In

JACC: Asia

DOI

EISSN

2772-3747

Publication Date

June 1, 2022

Volume

2

Issue

3P2

Start / End Page

323 / 337