Mighty mouse breakthroughs: a Sox2-driven model for squamous cell lung cancer.
Publication
, Journal Article
Mukhopadhyay, A; Oliver, TG
Published in: Mol Cell Oncol
2015
Squamous lung cancer is a subtype of non-small cell lung cancer with a poor overall prognosis. We have recently generated a mouse model of squamous lung carcinoma by overexpressing Sex-determining region Y-box 2 (Sox2) and deleting liver kinase B1 (Lkb1) using a lentiviral approach. This model recapitulates the human disease in terms of histopathology, biomarker expression, and signaling pathway activation, making it an excellent model for preclinical studies.
Duke Scholars
Published In
Mol Cell Oncol
DOI
ISSN
2372-3556
Publication Date
2015
Volume
2
Issue
2
Start / End Page
e969651
Location
United States
Related Subject Headings
- 3211 Oncology and carcinogenesis
- 3205 Medical biochemistry and metabolomics
Citation
APA
Chicago
ICMJE
MLA
NLM
Mukhopadhyay, A., & Oliver, T. G. (2015). Mighty mouse breakthroughs: a Sox2-driven model for squamous cell lung cancer. Mol Cell Oncol, 2(2), e969651. https://doi.org/10.4161/23723548.2014.969651
Mukhopadhyay, Anandaroop, and Trudy G. Oliver. “Mighty mouse breakthroughs: a Sox2-driven model for squamous cell lung cancer.” Mol Cell Oncol 2, no. 2 (2015): e969651. https://doi.org/10.4161/23723548.2014.969651.
Mukhopadhyay A, Oliver TG. Mighty mouse breakthroughs: a Sox2-driven model for squamous cell lung cancer. Mol Cell Oncol. 2015;2(2):e969651.
Mukhopadhyay, Anandaroop, and Trudy G. Oliver. “Mighty mouse breakthroughs: a Sox2-driven model for squamous cell lung cancer.” Mol Cell Oncol, vol. 2, no. 2, 2015, p. e969651. Pubmed, doi:10.4161/23723548.2014.969651.
Mukhopadhyay A, Oliver TG. Mighty mouse breakthroughs: a Sox2-driven model for squamous cell lung cancer. Mol Cell Oncol. 2015;2(2):e969651.
Published In
Mol Cell Oncol
DOI
ISSN
2372-3556
Publication Date
2015
Volume
2
Issue
2
Start / End Page
e969651
Location
United States
Related Subject Headings
- 3211 Oncology and carcinogenesis
- 3205 Medical biochemistry and metabolomics