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Sox2 cooperates with Lkb1 loss in a mouse model of squamous cell lung cancer.

Publication ,  Journal Article
Mukhopadhyay, A; Berrett, KC; Kc, U; Clair, PM; Pop, SM; Carr, SR; Witt, BL; Oliver, TG
Published in: Cell Rep
July 10, 2014

Squamous cell carcinoma (SCC) of the lung is the second most common subtype of lung cancer. With limited treatment options, the 5-year survival rate of SCC is only 15%. Although genomic alterations in SCC have been characterized, identifying the alterations that drive SCC is critical for improving treatment strategies. Mouse models of SCC are currently limited. Using lentiviral delivery of Sox2 specifically to the mouse lung, we tested the ability of Sox2 to promote tumorigenesis in multiple tumor suppressor backgrounds. Expression of Sox2, frequently amplified in human SCC, specifically cooperates with loss of Lkb1 to promote squamous lung tumors. Mouse tumors exhibit characteristic histopathology and biomarker expression similar to human SCC. They also mimic human SCCs by activation of therapeutically relevant pathways including STAT and mTOR. This model may be utilized to test the contribution of additional driver alterations in SCC, as well as for preclinical drug discovery.

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Published In

Cell Rep

DOI

EISSN

2211-1247

Publication Date

July 10, 2014

Volume

8

Issue

1

Start / End Page

40 / 49

Location

United States

Related Subject Headings

  • TOR Serine-Threonine Kinases
  • STAT Transcription Factors
  • SOXB1 Transcription Factors
  • Protein Serine-Threonine Kinases
  • Mice
  • Lung Neoplasms
  • Humans
  • Carcinoma, Squamous Cell
  • Carcinogenesis
  • Biomarkers, Tumor
 

Citation

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Mukhopadhyay, A., Berrett, K. C., Kc, U., Clair, P. M., Pop, S. M., Carr, S. R., … Oliver, T. G. (2014). Sox2 cooperates with Lkb1 loss in a mouse model of squamous cell lung cancer. Cell Rep, 8(1), 40–49. https://doi.org/10.1016/j.celrep.2014.05.036
Mukhopadhyay, Anandaroop, Kristofer C. Berrett, Ushma Kc, Phillip M. Clair, Stelian M. Pop, Shamus R. Carr, Benjamin L. Witt, and Trudy G. Oliver. “Sox2 cooperates with Lkb1 loss in a mouse model of squamous cell lung cancer.Cell Rep 8, no. 1 (July 10, 2014): 40–49. https://doi.org/10.1016/j.celrep.2014.05.036.
Mukhopadhyay A, Berrett KC, Kc U, Clair PM, Pop SM, Carr SR, et al. Sox2 cooperates with Lkb1 loss in a mouse model of squamous cell lung cancer. Cell Rep. 2014 Jul 10;8(1):40–9.
Mukhopadhyay, Anandaroop, et al. “Sox2 cooperates with Lkb1 loss in a mouse model of squamous cell lung cancer.Cell Rep, vol. 8, no. 1, July 2014, pp. 40–49. Pubmed, doi:10.1016/j.celrep.2014.05.036.
Mukhopadhyay A, Berrett KC, Kc U, Clair PM, Pop SM, Carr SR, Witt BL, Oliver TG. Sox2 cooperates with Lkb1 loss in a mouse model of squamous cell lung cancer. Cell Rep. 2014 Jul 10;8(1):40–49.
Journal cover image

Published In

Cell Rep

DOI

EISSN

2211-1247

Publication Date

July 10, 2014

Volume

8

Issue

1

Start / End Page

40 / 49

Location

United States

Related Subject Headings

  • TOR Serine-Threonine Kinases
  • STAT Transcription Factors
  • SOXB1 Transcription Factors
  • Protein Serine-Threonine Kinases
  • Mice
  • Lung Neoplasms
  • Humans
  • Carcinoma, Squamous Cell
  • Carcinogenesis
  • Biomarkers, Tumor