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Adiponectin preserves metabolic fitness during aging.

Publication ,  Journal Article
Li, N; Zhao, S; Zhang, Z; Zhu, Y; Gliniak, CM; Vishvanath, L; An, YA; Wang, M-Y; Deng, Y; Zhu, Q; Shan, B; Sherwood, A; Onodera, T; Oz, OK ...
Published in: Elife
April 27, 2021

Adiponectin is essential for the regulation of tissue substrate utilization and systemic insulin sensitivity. Clinical studies have suggested a positive association of circulating adiponectin with healthspan and lifespan. However, the direct effects of adiponectin on promoting healthspan and lifespan remain unexplored. Here, we are using an adiponectin null mouse and a transgenic adiponectin overexpression model. We directly assessed the effects of circulating adiponectin on the aging process and found that adiponectin null mice display exacerbated age-related glucose and lipid metabolism disorders. Moreover, adiponectin null mice have a significantly shortened lifespan on both chow and high-fat diet. In contrast, a transgenic mouse model with elevated circulating adiponectin levels has a dramatically improved systemic insulin sensitivity, reduced age-related tissue inflammation and fibrosis, and a prolonged healthspan and median lifespan. These results support a role of adiponectin as an essential regulator for healthspan and lifespan.

Duke Scholars

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Published In

Elife

DOI

EISSN

2050-084X

Publication Date

April 27, 2021

Volume

10

Location

England

Related Subject Headings

  • Mice, Transgenic
  • Mice
  • Male
  • Longevity
  • Lipid Metabolism
  • Insulin Resistance
  • Homeostasis
  • Glucose
  • Female
  • Animals
 

Citation

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Li, N., Zhao, S., Zhang, Z., Zhu, Y., Gliniak, C. M., Vishvanath, L., … Scherer, P. E. (2021). Adiponectin preserves metabolic fitness during aging. Elife, 10. https://doi.org/10.7554/eLife.65108
Li, Na, Shangang Zhao, Zhuzhen Zhang, Yi Zhu, Christy M. Gliniak, Lavanya Vishvanath, Yu A. An, et al. “Adiponectin preserves metabolic fitness during aging.Elife 10 (April 27, 2021). https://doi.org/10.7554/eLife.65108.
Li N, Zhao S, Zhang Z, Zhu Y, Gliniak CM, Vishvanath L, et al. Adiponectin preserves metabolic fitness during aging. Elife. 2021 Apr 27;10.
Li, Na, et al. “Adiponectin preserves metabolic fitness during aging.Elife, vol. 10, Apr. 2021. Pubmed, doi:10.7554/eLife.65108.
Li N, Zhao S, Zhang Z, Zhu Y, Gliniak CM, Vishvanath L, An YA, Wang M-Y, Deng Y, Zhu Q, Shan B, Sherwood A, Onodera T, Oz OK, Gordillo R, Gupta RK, Liu M, Horvath TL, Dixit VD, Scherer PE. Adiponectin preserves metabolic fitness during aging. Elife. 2021 Apr 27;10.

Published In

Elife

DOI

EISSN

2050-084X

Publication Date

April 27, 2021

Volume

10

Location

England

Related Subject Headings

  • Mice, Transgenic
  • Mice
  • Male
  • Longevity
  • Lipid Metabolism
  • Insulin Resistance
  • Homeostasis
  • Glucose
  • Female
  • Animals