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Contribution of adipogenesis to healthy adipose tissue expansion in obesity.

Publication ,  Journal Article
Vishvanath, L; Gupta, RK
Published in: J Clin Invest
October 1, 2019

The manner in which white adipose tissue (WAT) expands and remodels directly impacts the risk of developing metabolic syndrome in obesity. Preferential accumulation of visceral WAT is associated with increased risk for insulin resistance, whereas subcutaneous WAT expansion is protective. Moreover, pathologic WAT remodeling, typically characterized by adipocyte hypertrophy, chronic inflammation, and fibrosis, is associated with insulin resistance. Healthy WAT expansion, observed in the "metabolically healthy" obese, is generally associated with the presence of smaller and more numerous adipocytes, along with lower degrees of inflammation and fibrosis. Here, we highlight recent human and rodent studies that support the notion that the ability to recruit new fat cells through adipogenesis is a critical determinant of healthy adipose tissue distribution and remodeling in obesity. Furthermore, we discuss recent advances in our understanding of the identity of tissue-resident progenitor populations in WAT made possible through single-cell RNA sequencing analysis. A better understanding of adipose stem cell biology and adipogenesis may lead to novel strategies to uncouple obesity from metabolic disease.

Duke Scholars

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Published In

J Clin Invest

DOI

EISSN

1558-8238

Publication Date

October 1, 2019

Volume

129

Issue

10

Start / End Page

4022 / 4031

Location

United States

Related Subject Headings

  • Stem Cells
  • Single-Cell Analysis
  • Risk Factors
  • RNA-Seq
  • Obesity
  • Mice
  • Metabolic Syndrome
  • Insulin Resistance
  • Immunology
  • Humans
 

Citation

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Vishvanath, L., & Gupta, R. K. (2019). Contribution of adipogenesis to healthy adipose tissue expansion in obesity. J Clin Invest, 129(10), 4022–4031. https://doi.org/10.1172/JCI129191
Vishvanath, Lavanya, and Rana K. Gupta. “Contribution of adipogenesis to healthy adipose tissue expansion in obesity.J Clin Invest 129, no. 10 (October 1, 2019): 4022–31. https://doi.org/10.1172/JCI129191.
Vishvanath L, Gupta RK. Contribution of adipogenesis to healthy adipose tissue expansion in obesity. J Clin Invest. 2019 Oct 1;129(10):4022–31.
Vishvanath, Lavanya, and Rana K. Gupta. “Contribution of adipogenesis to healthy adipose tissue expansion in obesity.J Clin Invest, vol. 129, no. 10, Oct. 2019, pp. 4022–31. Pubmed, doi:10.1172/JCI129191.
Vishvanath L, Gupta RK. Contribution of adipogenesis to healthy adipose tissue expansion in obesity. J Clin Invest. 2019 Oct 1;129(10):4022–4031.

Published In

J Clin Invest

DOI

EISSN

1558-8238

Publication Date

October 1, 2019

Volume

129

Issue

10

Start / End Page

4022 / 4031

Location

United States

Related Subject Headings

  • Stem Cells
  • Single-Cell Analysis
  • Risk Factors
  • RNA-Seq
  • Obesity
  • Mice
  • Metabolic Syndrome
  • Insulin Resistance
  • Immunology
  • Humans