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Transcriptional brakes on the road to adipocyte thermogenesis.

Publication ,  Journal Article
Shao, M; Gupta, RK
Published in: Biochim Biophys Acta Mol Cell Biol Lipids
January 2019

White adipocytes represent the principle site for energy storage whereas brown/beige adipocytes emerge from seemingly distinct cellular lineages and burn chemical energy to produce heat. Thermogenic adipocytes utilize cell-type selective master regulatory transcription factors to drive the expression of their adipocyte thermogenic gene program. White adipocytes harbor transcriptional mechanisms to suppress the thermogenic gene program and maintain an energy-storing function. Here, we summarize some of the key developmental and transcriptional mechanisms leading to the postnatal recruitment of thermogenic adipocytes under physiological conditions, with a particular emphasis on the transcriptional "brakes" on the thermogenic gene program. We highlight a number of recent studies, including our own work on the transcription factor, ZFP423, that illustrate the potential to engineer the subcutaneous and visceral white fat lineages to adopt a thermogenic fat cell fate by releasing the inhibition of the adipocyte thermogenic gene program. These transcriptional brakes on adipocyte thermogenesis may represent potential targets of therapeutic interventions designed to combat obesity and associated metabolic disorders.

Duke Scholars

Published In

Biochim Biophys Acta Mol Cell Biol Lipids

DOI

EISSN

1879-2618

Publication Date

January 2019

Volume

1864

Issue

1

Start / End Page

20 / 28

Location

Netherlands

Related Subject Headings

  • Transcription, Genetic
  • Thermogenesis
  • Humans
  • Genetic Engineering
  • Animals
  • Adipose Tissue, White
  • Adipocytes
  • 42 Health sciences
  • 32 Biomedical and clinical sciences
  • 31 Biological sciences
 

Citation

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Shao, M., & Gupta, R. K. (2019). Transcriptional brakes on the road to adipocyte thermogenesis. Biochim Biophys Acta Mol Cell Biol Lipids, 1864(1), 20–28. https://doi.org/10.1016/j.bbalip.2018.05.010
Shao, Mengle, and Rana K. Gupta. “Transcriptional brakes on the road to adipocyte thermogenesis.Biochim Biophys Acta Mol Cell Biol Lipids 1864, no. 1 (January 2019): 20–28. https://doi.org/10.1016/j.bbalip.2018.05.010.
Shao M, Gupta RK. Transcriptional brakes on the road to adipocyte thermogenesis. Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Jan;1864(1):20–8.
Shao, Mengle, and Rana K. Gupta. “Transcriptional brakes on the road to adipocyte thermogenesis.Biochim Biophys Acta Mol Cell Biol Lipids, vol. 1864, no. 1, Jan. 2019, pp. 20–28. Pubmed, doi:10.1016/j.bbalip.2018.05.010.
Shao M, Gupta RK. Transcriptional brakes on the road to adipocyte thermogenesis. Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Jan;1864(1):20–28.

Published In

Biochim Biophys Acta Mol Cell Biol Lipids

DOI

EISSN

1879-2618

Publication Date

January 2019

Volume

1864

Issue

1

Start / End Page

20 / 28

Location

Netherlands

Related Subject Headings

  • Transcription, Genetic
  • Thermogenesis
  • Humans
  • Genetic Engineering
  • Animals
  • Adipose Tissue, White
  • Adipocytes
  • 42 Health sciences
  • 32 Biomedical and clinical sciences
  • 31 Biological sciences