Identifying novel transcriptional components controlling energy metabolism.
Publication
, Journal Article
Gupta, RK; Rosen, ED; Spiegelman, BM
Published in: Cell Metab
December 7, 2011
The investigation of metabolic regulation at the transcriptional level presents different challenges than those encountered in the study of other important problems like development or cancer. Levels of key components like glucose, insulin, and lipids can be modulated but rarely change in an all-or-none fashion, necessitating quantitative techniques that can be applied to multiple tissues and systems. This review examines recent advances in methods for studying transcriptional regulation, with special emphasis on metabolic science. We compare these methods for investigators trying to decide on the best approach for their particular physiological paradigm or model system.
Duke Scholars
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Published In
Cell Metab
DOI
EISSN
1932-7420
Publication Date
December 7, 2011
Volume
14
Issue
6
Start / End Page
739 / 745
Location
United States
Related Subject Headings
- Transcriptional Activation
- Transcription Factors
- Sequence Analysis, DNA
- Regulatory Elements, Transcriptional
- Polymerase Chain Reaction
- Gene Expression Profiling
- Energy Metabolism
- Endocrinology & Metabolism
- Computational Biology
- Chromatin Immunoprecipitation
Citation
APA
Chicago
ICMJE
MLA
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Gupta, R. K., Rosen, E. D., & Spiegelman, B. M. (2011). Identifying novel transcriptional components controlling energy metabolism. Cell Metab, 14(6), 739–745. https://doi.org/10.1016/j.cmet.2011.11.007
Gupta, Rana K., Evan D. Rosen, and Bruce M. Spiegelman. “Identifying novel transcriptional components controlling energy metabolism.” Cell Metab 14, no. 6 (December 7, 2011): 739–45. https://doi.org/10.1016/j.cmet.2011.11.007.
Gupta RK, Rosen ED, Spiegelman BM. Identifying novel transcriptional components controlling energy metabolism. Cell Metab. 2011 Dec 7;14(6):739–45.
Gupta, Rana K., et al. “Identifying novel transcriptional components controlling energy metabolism.” Cell Metab, vol. 14, no. 6, Dec. 2011, pp. 739–45. Pubmed, doi:10.1016/j.cmet.2011.11.007.
Gupta RK, Rosen ED, Spiegelman BM. Identifying novel transcriptional components controlling energy metabolism. Cell Metab. 2011 Dec 7;14(6):739–745.
Published In
Cell Metab
DOI
EISSN
1932-7420
Publication Date
December 7, 2011
Volume
14
Issue
6
Start / End Page
739 / 745
Location
United States
Related Subject Headings
- Transcriptional Activation
- Transcription Factors
- Sequence Analysis, DNA
- Regulatory Elements, Transcriptional
- Polymerase Chain Reaction
- Gene Expression Profiling
- Energy Metabolism
- Endocrinology & Metabolism
- Computational Biology
- Chromatin Immunoprecipitation