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Post-Translational Modifications of Proteins in Cytosolic Nucleic Acid Sensing Signaling Pathways.

Publication ,  Journal Article
Deng, Y; Wang, Y; Li, L; Miao, EA; Liu, P
Published in: Front Immunol
2022

The innate immune response is the first-line host defense against pathogens. Cytosolic nucleic acids, including both DNA and RNA, represent a special type of danger signal to initiate an innate immune response. Activation of cytosolic nucleic acid sensors is tightly controlled in order to achieve the high sensitivity needed to combat infection while simultaneously preventing false activation that leads to pathologic inflammatory diseases. In this review, we focus on post-translational modifications of key cytosolic nucleic acid sensors that can reversibly or irreversibly control these sensor functions. We will describe phosphorylation, ubiquitination, SUMOylation, neddylation, acetylation, methylation, succinylation, glutamylation, amidation, palmitoylation, and oxidation modifications events (including modified residues, modifying enzymes, and modification function). Together, these post-translational regulatory modifications on key cytosolic DNA/RNA sensing pathway members reveal a complicated yet elegantly controlled multilayer regulator network to govern innate immune activation.

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Published In

Front Immunol

DOI

EISSN

1664-3224

Publication Date

2022

Volume

13

Start / End Page

898724

Location

Switzerland

Related Subject Headings

  • Signal Transduction
  • RNA
  • Protein Processing, Post-Translational
  • Nucleic Acids
  • DNA
  • 3204 Immunology
  • 3105 Genetics
  • 3101 Biochemistry and cell biology
  • 1108 Medical Microbiology
  • 1107 Immunology
 

Citation

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Deng, Y., Wang, Y., Li, L., Miao, E. A., & Liu, P. (2022). Post-Translational Modifications of Proteins in Cytosolic Nucleic Acid Sensing Signaling Pathways. Front Immunol, 13, 898724. https://doi.org/10.3389/fimmu.2022.898724
Deng, Yu, Ying Wang, Lupeng Li, Edward A. Miao, and Pengda Liu. “Post-Translational Modifications of Proteins in Cytosolic Nucleic Acid Sensing Signaling Pathways.Front Immunol 13 (2022): 898724. https://doi.org/10.3389/fimmu.2022.898724.
Deng Y, Wang Y, Li L, Miao EA, Liu P. Post-Translational Modifications of Proteins in Cytosolic Nucleic Acid Sensing Signaling Pathways. Front Immunol. 2022;13:898724.
Deng, Yu, et al. “Post-Translational Modifications of Proteins in Cytosolic Nucleic Acid Sensing Signaling Pathways.Front Immunol, vol. 13, 2022, p. 898724. Pubmed, doi:10.3389/fimmu.2022.898724.
Deng Y, Wang Y, Li L, Miao EA, Liu P. Post-Translational Modifications of Proteins in Cytosolic Nucleic Acid Sensing Signaling Pathways. Front Immunol. 2022;13:898724.

Published In

Front Immunol

DOI

EISSN

1664-3224

Publication Date

2022

Volume

13

Start / End Page

898724

Location

Switzerland

Related Subject Headings

  • Signal Transduction
  • RNA
  • Protein Processing, Post-Translational
  • Nucleic Acids
  • DNA
  • 3204 Immunology
  • 3105 Genetics
  • 3101 Biochemistry and cell biology
  • 1108 Medical Microbiology
  • 1107 Immunology