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Particle hydrogels decrease cerebral atrophy and attenuate astrocyte and microglia/macrophage reactivity after stroke.

Publication ,  Journal Article
Sideris, E; Kioulaphides, S; Wilson, K; Yu, A; Chen, J; Carmichael, ST; Segura, T
Published in: Advanced therapeutics
August 2022

Increasing numbers of individuals live with stroke related disabilities. Following stroke, highly reactive astrocytes and pro-inflammatory microglia can release cytokines and lead to a cytotoxic environment that causes further brain damage and prevents endogenous repair. Paradoxically, these same cells also activate pro-repair mechanisms that contribute to endogenous repair and brain plasticity. Here, we show that the direct injection of a hyaluronic acid based microporous annealed particle (MAP) hydrogel into the stroke core in mice reduces the percent of highly reactive astrocytes, increases the percent of alternatively activated microglia, decreases cerebral atrophy and preserves NF200 axonal bundles. Further, we show that MAP hydrogel promotes reparative astrocyte infiltration into the lesion, which directly coincides with axonal penetration into the lesion. This work shows that the injection of a porous scaffold into the stroke core can lead to clinically relevant decrease in cerebral atrophy and modulates astrocytes and microglia towards a pro-repair phenotype.

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Published In

Advanced therapeutics

DOI

EISSN

2366-3987

ISSN

2366-3987

Publication Date

August 2022

Volume

5

Issue

8

Start / End Page

2200048

Related Subject Headings

  • 3214 Pharmacology and pharmaceutical sciences
  • 3206 Medical biotechnology
  • 3101 Biochemistry and cell biology
 

Citation

APA
Chicago
ICMJE
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Sideris, E., Kioulaphides, S., Wilson, K., Yu, A., Chen, J., Carmichael, S. T., & Segura, T. (2022). Particle hydrogels decrease cerebral atrophy and attenuate astrocyte and microglia/macrophage reactivity after stroke. Advanced Therapeutics, 5(8), 2200048. https://doi.org/10.1002/adtp.202200048
Sideris, Elias, Sophia Kioulaphides, Katrina Wilson, Aaron Yu, Jun Chen, S Thomas Carmichael, and Tatiana Segura. “Particle hydrogels decrease cerebral atrophy and attenuate astrocyte and microglia/macrophage reactivity after stroke.Advanced Therapeutics 5, no. 8 (August 2022): 2200048. https://doi.org/10.1002/adtp.202200048.
Sideris E, Kioulaphides S, Wilson K, Yu A, Chen J, Carmichael ST, et al. Particle hydrogels decrease cerebral atrophy and attenuate astrocyte and microglia/macrophage reactivity after stroke. Advanced therapeutics. 2022 Aug;5(8):2200048.
Sideris, Elias, et al. “Particle hydrogels decrease cerebral atrophy and attenuate astrocyte and microglia/macrophage reactivity after stroke.Advanced Therapeutics, vol. 5, no. 8, Aug. 2022, p. 2200048. Epmc, doi:10.1002/adtp.202200048.
Sideris E, Kioulaphides S, Wilson K, Yu A, Chen J, Carmichael ST, Segura T. Particle hydrogels decrease cerebral atrophy and attenuate astrocyte and microglia/macrophage reactivity after stroke. Advanced therapeutics. 2022 Aug;5(8):2200048.

Published In

Advanced therapeutics

DOI

EISSN

2366-3987

ISSN

2366-3987

Publication Date

August 2022

Volume

5

Issue

8

Start / End Page

2200048

Related Subject Headings

  • 3214 Pharmacology and pharmaceutical sciences
  • 3206 Medical biotechnology
  • 3101 Biochemistry and cell biology