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Glucagon Receptor Antagonism Ameliorates Progression of Heart Failure.

Publication ,  Journal Article
Gao, C; Ren, SV; Yu, J; Baal, U; Thai, D; Lu, J; Zeng, C; Yan, H; Wang, Y
Published in: JACC Basic Transl Sci
April 2019

Mice were treated with a fully human monoclonal glucagon receptor antagonistic antibody REMD2.59 following myocardial infarction or pressure overload. REMD2.59 treatment blunted cardiac hypertrophy and fibrotic remodeling, and attenuated contractile dysfunction at 4 weeks after myocardial infarction. In addition, REMD2.59 treatment at the onset of pressure overload significantly suppressed cardiac hypertrophy and chamber dilation with marked preservation of cardiac systolic and diastolic function. Initiation of REMD2.59 treatment 2 weeks after pressure overload significantly blunted the progression of cardiac pathology. These results provide the first in vivo proof-of-concept evidence that glucagon receptor antagonism is a potentially efficacious therapy to ameliorate both onset and progression of heart failure.

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Published In

JACC Basic Transl Sci

DOI

EISSN

2452-302X

Publication Date

April 2019

Volume

4

Issue

2

Start / End Page

161 / 172

Location

United States

Related Subject Headings

  • 3201 Cardiovascular medicine and haematology
  • 1103 Clinical Sciences
  • 1102 Cardiorespiratory Medicine and Haematology
 

Citation

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Gao, C., Ren, S. V., Yu, J., Baal, U., Thai, D., Lu, J., … Wang, Y. (2019). Glucagon Receptor Antagonism Ameliorates Progression of Heart Failure. JACC Basic Transl Sci, 4(2), 161–172. https://doi.org/10.1016/j.jacbts.2018.11.001
Gao, Chen, Shuxun Vincent Ren, Junyi Yu, Ulysis Baal, Dung Thai, John Lu, Chunyu Zeng, Hai Yan, and Yibin Wang. “Glucagon Receptor Antagonism Ameliorates Progression of Heart Failure.JACC Basic Transl Sci 4, no. 2 (April 2019): 161–72. https://doi.org/10.1016/j.jacbts.2018.11.001.
Gao C, Ren SV, Yu J, Baal U, Thai D, Lu J, et al. Glucagon Receptor Antagonism Ameliorates Progression of Heart Failure. JACC Basic Transl Sci. 2019 Apr;4(2):161–72.
Gao, Chen, et al. “Glucagon Receptor Antagonism Ameliorates Progression of Heart Failure.JACC Basic Transl Sci, vol. 4, no. 2, Apr. 2019, pp. 161–72. Pubmed, doi:10.1016/j.jacbts.2018.11.001.
Gao C, Ren SV, Yu J, Baal U, Thai D, Lu J, Zeng C, Yan H, Wang Y. Glucagon Receptor Antagonism Ameliorates Progression of Heart Failure. JACC Basic Transl Sci. 2019 Apr;4(2):161–172.
Journal cover image

Published In

JACC Basic Transl Sci

DOI

EISSN

2452-302X

Publication Date

April 2019

Volume

4

Issue

2

Start / End Page

161 / 172

Location

United States

Related Subject Headings

  • 3201 Cardiovascular medicine and haematology
  • 1103 Clinical Sciences
  • 1102 Cardiorespiratory Medicine and Haematology