Skip to main content
release_alert
Welcome to the new Scholars 3.0! Read about new features and let us know what you think.
cancel
Journal cover image

Nuclear phosphatase PPM1G in cellular survival and neural development.

Publication ,  Journal Article
Foster, WH; Langenbacher, A; Gao, C; Chen, J; Wang, Y
Published in: Dev Dyn
September 2013

BACKGROUND: PPM1G is a nuclear localized serine/threonine phosphatase implicated to be a regulator of chromatin remodeling, mRNA splicing, and DNA damage. However, its in vivo function is unknown. RESULTS: Here we show that ppm1g expression is highly enriched in the central nervous system during mouse and zebrafish development. ppm1g(-/-) mice were embryonic lethal with incomplete penetrance after E12.5. Rostral defects, including neural tube and craniofacial defects were observed in ppm1g(-/-) embryos associated with increased cell death in the neural epithelium. In zebrafish, loss of ppm1g also led to neural defects with aberrant neural marker gene expression. Primary fibroblasts from ppm1g(-/-) embryos failed to grow without immortalization while immortalized ppm1g(-/-) fibroblasts had increased cell death upon oxidative and genotoxic stress when compared to wild type fibroblasts. CONCLUSIONS: Our in vivo and in vitro studies revealed a critical role for PPM1G in normal development and cell survival.

Duke Scholars

Published In

Dev Dyn

DOI

EISSN

1097-0177

Publication Date

September 2013

Volume

242

Issue

9

Start / End Page

1101 / 1109

Location

United States

Related Subject Headings

  • Zebrafish Proteins
  • Zebrafish
  • Protein Phosphatase 2C
  • Phosphoprotein Phosphatases
  • Neurogenesis
  • Neural Tube
  • Nerve Tissue Proteins
  • Mice, Knockout
  • Mice
  • Gene Expression Regulation, Developmental
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Foster, W. H., Langenbacher, A., Gao, C., Chen, J., & Wang, Y. (2013). Nuclear phosphatase PPM1G in cellular survival and neural development. Dev Dyn, 242(9), 1101–1109. https://doi.org/10.1002/dvdy.23990
Foster, William H., Adam Langenbacher, Chen Gao, Jaunian Chen, and Yibin Wang. “Nuclear phosphatase PPM1G in cellular survival and neural development.Dev Dyn 242, no. 9 (September 2013): 1101–9. https://doi.org/10.1002/dvdy.23990.
Foster WH, Langenbacher A, Gao C, Chen J, Wang Y. Nuclear phosphatase PPM1G in cellular survival and neural development. Dev Dyn. 2013 Sep;242(9):1101–9.
Foster, William H., et al. “Nuclear phosphatase PPM1G in cellular survival and neural development.Dev Dyn, vol. 242, no. 9, Sept. 2013, pp. 1101–09. Pubmed, doi:10.1002/dvdy.23990.
Foster WH, Langenbacher A, Gao C, Chen J, Wang Y. Nuclear phosphatase PPM1G in cellular survival and neural development. Dev Dyn. 2013 Sep;242(9):1101–1109.
Journal cover image

Published In

Dev Dyn

DOI

EISSN

1097-0177

Publication Date

September 2013

Volume

242

Issue

9

Start / End Page

1101 / 1109

Location

United States

Related Subject Headings

  • Zebrafish Proteins
  • Zebrafish
  • Protein Phosphatase 2C
  • Phosphoprotein Phosphatases
  • Neurogenesis
  • Neural Tube
  • Nerve Tissue Proteins
  • Mice, Knockout
  • Mice
  • Gene Expression Regulation, Developmental