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Hybrid mouse diversity panel: a panel of inbred mouse strains suitable for analysis of complex genetic traits.

Publication ,  Journal Article
Ghazalpour, A; Rau, CD; Farber, CR; Bennett, BJ; Orozco, LD; van Nas, A; Pan, C; Allayee, H; Beaven, SW; Civelek, M; Davis, RC; Drake, TA ...
Published in: Mamm Genome
October 2012

We have developed an association-based approach using classical inbred strains of mice in which we correct for population structure, which is very extensive in mice, using an efficient mixed-model algorithm. Our approach includes inbred parental strains as well as recombinant inbred strains in order to capture loci with effect sizes typical of complex traits in mice (in the range of 5% of total trait variance). Over the last few years, we have typed the hybrid mouse diversity panel (HMDP) strains for a variety of clinical traits as well as intermediate phenotypes and have shown that the HMDP has sufficient power to map genes for highly complex traits with resolution that is in most cases less than a megabase. In this essay, we review our experience with the HMDP, describe various ongoing projects, and discuss how the HMDP may fit into the larger picture of common diseases and different approaches.

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Published In

Mamm Genome

DOI

EISSN

1432-1777

Publication Date

October 2012

Volume

23

Issue

9-10

Start / End Page

680 / 692

Location

United States

Related Subject Headings

  • Mice, Inbred Strains
  • Mice
  • Genetics & Heredity
  • Databases, Genetic
  • Animals
  • 3105 Genetics
  • 0604 Genetics
 

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Ghazalpour, A., Rau, C. D., Farber, C. R., Bennett, B. J., Orozco, L. D., van Nas, A., … LeBoeuf, R. C. (2012). Hybrid mouse diversity panel: a panel of inbred mouse strains suitable for analysis of complex genetic traits. Mamm Genome, 23(9–10), 680–692. https://doi.org/10.1007/s00335-012-9411-5
Ghazalpour, Anatole, Christoph D. Rau, Charles R. Farber, Brian J. Bennett, Luz D. Orozco, Atila van Nas, Calvin Pan, et al. “Hybrid mouse diversity panel: a panel of inbred mouse strains suitable for analysis of complex genetic traits.Mamm Genome 23, no. 9–10 (October 2012): 680–92. https://doi.org/10.1007/s00335-012-9411-5.
Ghazalpour A, Rau CD, Farber CR, Bennett BJ, Orozco LD, van Nas A, et al. Hybrid mouse diversity panel: a panel of inbred mouse strains suitable for analysis of complex genetic traits. Mamm Genome. 2012 Oct;23(9–10):680–92.
Ghazalpour, Anatole, et al. “Hybrid mouse diversity panel: a panel of inbred mouse strains suitable for analysis of complex genetic traits.Mamm Genome, vol. 23, no. 9–10, Oct. 2012, pp. 680–92. Pubmed, doi:10.1007/s00335-012-9411-5.
Ghazalpour A, Rau CD, Farber CR, Bennett BJ, Orozco LD, van Nas A, Pan C, Allayee H, Beaven SW, Civelek M, Davis RC, Drake TA, Friedman RA, Furlotte N, Hui ST, Jentsch JD, Kostem E, Kang HM, Kang EY, Joo JW, Korshunov VA, Laughlin RE, Martin LJ, Ohmen JD, Parks BW, Pellegrini M, Reue K, Smith DJ, Tetradis S, Wang J, Wang Y, Weiss JN, Kirchgessner T, Gargalovic PS, Eskin E, Lusis AJ, LeBoeuf RC. Hybrid mouse diversity panel: a panel of inbred mouse strains suitable for analysis of complex genetic traits. Mamm Genome. 2012 Oct;23(9–10):680–692.
Journal cover image

Published In

Mamm Genome

DOI

EISSN

1432-1777

Publication Date

October 2012

Volume

23

Issue

9-10

Start / End Page

680 / 692

Location

United States

Related Subject Headings

  • Mice, Inbred Strains
  • Mice
  • Genetics & Heredity
  • Databases, Genetic
  • Animals
  • 3105 Genetics
  • 0604 Genetics