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Loss of Bmx nonreceptor tyrosine kinase prevents pressure overload-induced cardiac hypertrophy.

Publication ,  Journal Article
Mitchell-Jordan, SA; Holopainen, T; Ren, S; Wang, S; Warburton, S; Zhang, MJ; Alitalo, K; Wang, Y; Vondriska, TM
Published in: Circ Res
December 5, 2008

Bmx nonreceptor tyrosine kinase has an established role in endothelial and lymphocyte signaling; however, its role in the heart is unknown. To determine whether Bmx participates in cardiac growth, we subjected mice deficient in the molecule (Bmx knockout mice) to transverse aortic constriction (TAC). In comparison with wild-type mice, which progressively developed massive hypertrophy following TAC, Bmx knockout mice were resistant to TAC-induced cardiac growth at the organ and cell level. Loss of Bmx preserved cardiac ejection fraction and decreased mortality following TAC. These findings are the first to demonstrate a necessary role for the Tec family of tyrosine kinases in the heart and reveal a novel regulator (Bmx) of pressure overload-induced hypertrophic growth.

Duke Scholars

Published In

Circ Res

DOI

EISSN

1524-4571

Publication Date

December 5, 2008

Volume

103

Issue

12

Start / End Page

1359 / 1362

Location

United States

Related Subject Headings

  • Protein-Tyrosine Kinases
  • Mice, Knockout
  • Mice, Inbred BALB C
  • Mice
  • Male
  • Cardiovascular System & Hematology
  • Cardiomegaly
  • Blood Pressure
  • Animals
  • 3202 Clinical sciences
 

Citation

APA
Chicago
ICMJE
MLA
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Mitchell-Jordan, S. A., Holopainen, T., Ren, S., Wang, S., Warburton, S., Zhang, M. J., … Vondriska, T. M. (2008). Loss of Bmx nonreceptor tyrosine kinase prevents pressure overload-induced cardiac hypertrophy. Circ Res, 103(12), 1359–1362. https://doi.org/10.1161/CIRCRESAHA.108.186577
Mitchell-Jordan, Scherise A., Tanja Holopainen, Shuxun Ren, Sujing Wang, Sarah Warburton, Michael J. Zhang, Kari Alitalo, Yibin Wang, and Thomas M. Vondriska. “Loss of Bmx nonreceptor tyrosine kinase prevents pressure overload-induced cardiac hypertrophy.Circ Res 103, no. 12 (December 5, 2008): 1359–62. https://doi.org/10.1161/CIRCRESAHA.108.186577.
Mitchell-Jordan SA, Holopainen T, Ren S, Wang S, Warburton S, Zhang MJ, et al. Loss of Bmx nonreceptor tyrosine kinase prevents pressure overload-induced cardiac hypertrophy. Circ Res. 2008 Dec 5;103(12):1359–62.
Mitchell-Jordan, Scherise A., et al. “Loss of Bmx nonreceptor tyrosine kinase prevents pressure overload-induced cardiac hypertrophy.Circ Res, vol. 103, no. 12, Dec. 2008, pp. 1359–62. Pubmed, doi:10.1161/CIRCRESAHA.108.186577.
Mitchell-Jordan SA, Holopainen T, Ren S, Wang S, Warburton S, Zhang MJ, Alitalo K, Wang Y, Vondriska TM. Loss of Bmx nonreceptor tyrosine kinase prevents pressure overload-induced cardiac hypertrophy. Circ Res. 2008 Dec 5;103(12):1359–1362.

Published In

Circ Res

DOI

EISSN

1524-4571

Publication Date

December 5, 2008

Volume

103

Issue

12

Start / End Page

1359 / 1362

Location

United States

Related Subject Headings

  • Protein-Tyrosine Kinases
  • Mice, Knockout
  • Mice, Inbred BALB C
  • Mice
  • Male
  • Cardiovascular System & Hematology
  • Cardiomegaly
  • Blood Pressure
  • Animals
  • 3202 Clinical sciences