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Mitogen-activated protein kinases in heart development and diseases.

Publication ,  Journal Article
Wang, Y
Published in: Circulation
September 18, 2007

Mitogen-activated protein (MAP) kinases belong to a highly conserved family of Ser-Thr protein kinases in the human kinome and have diverse roles in broad physiological functions. The 4 best-characterized MAP kinase pathways, ERK1/2, JNK, p38, and ERK5, have been implicated in different aspects of cardiac regulation, from development to pathological remodeling. Recent advancements in the development of kinase-specific inhibitors and genetically engineered animal models have revealed significant new insights about MAP kinase pathways in the heart. However, this explosive body of new information also has yielded many controversies about the functional role of specific MAP kinases as either detrimental promoters or critical protectors of the heart during cardiac pathological processes. These uncertainties have raised questions on whether/how MAP kinases can be targeted to develop effective therapies against heart diseases. In this review, recent studies examining the role of MAP kinase subfamilies in cardiac development, hypertrophy, and survival are summarized.

Duke Scholars

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Published In

Circulation

DOI

EISSN

1524-4539

Publication Date

September 18, 2007

Volume

116

Issue

12

Start / End Page

1413 / 1423

Location

United States

Related Subject Headings

  • Protein Kinase Inhibitors
  • Myocardium
  • Mitogen-Activated Protein Kinases
  • Mice
  • MAP Kinase Signaling System
  • Humans
  • Heart Diseases
  • Heart Defects, Congenital
  • Fetal Heart
  • Drug Evaluation, Preclinical
 

Citation

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Wang, Y. (2007). Mitogen-activated protein kinases in heart development and diseases. Circulation, 116(12), 1413–1423. https://doi.org/10.1161/CIRCULATIONAHA.106.679589
Wang, Yibin. “Mitogen-activated protein kinases in heart development and diseases.Circulation 116, no. 12 (September 18, 2007): 1413–23. https://doi.org/10.1161/CIRCULATIONAHA.106.679589.
Wang Y. Mitogen-activated protein kinases in heart development and diseases. Circulation. 2007 Sep 18;116(12):1413–23.
Wang, Yibin. “Mitogen-activated protein kinases in heart development and diseases.Circulation, vol. 116, no. 12, Sept. 2007, pp. 1413–23. Pubmed, doi:10.1161/CIRCULATIONAHA.106.679589.
Wang Y. Mitogen-activated protein kinases in heart development and diseases. Circulation. 2007 Sep 18;116(12):1413–1423.

Published In

Circulation

DOI

EISSN

1524-4539

Publication Date

September 18, 2007

Volume

116

Issue

12

Start / End Page

1413 / 1423

Location

United States

Related Subject Headings

  • Protein Kinase Inhibitors
  • Myocardium
  • Mitogen-Activated Protein Kinases
  • Mice
  • MAP Kinase Signaling System
  • Humans
  • Heart Diseases
  • Heart Defects, Congenital
  • Fetal Heart
  • Drug Evaluation, Preclinical