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Branched-chain amino acid metabolism in heart disease: an epiphenomenon or a real culprit?

Publication ,  Journal Article
Huang, Y; Zhou, M; Sun, H; Wang, Y
Published in: Cardiovasc Res
May 1, 2011

Metabolic remodelling is an integral part of the pathogenesis of heart failure. Although much progress has been made in our current understanding of the metabolic impairment involving carbohydrates and fatty acids in failing hearts, relatively little is known about the changes and potential impact of amino acid metabolism in the onset of heart diseases. Although most amino acid catabolic activities are found in the liver, branched-chain amino acid (BCAA) catabolism requires activity in several non-hepatic tissues, including cardiac muscle, diaphragm, brain and kidney. In this review, the new insights into the regulation of cardiac BCAA catabolism and functional impact on cardiac development and physiology will be discussed along with the potential contribution of impairment in BCAA catabolism to heart diseases. A particular focus will be the new information obtained from recently developed genetic models with BCAA catabolic defects and metabolomic studies in human and animal models. These studies have revealed the potential role of BCAA catabolism in cardiac pathophysiology and have helped to distinguish BCAA metabolic defects as an under-appreciated culprit in cardiac diseases rather than an epiphenomenon associated with metabolic remodelling in the failing heart.

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Published In

Cardiovasc Res

DOI

EISSN

1755-3245

Publication Date

May 1, 2011

Volume

90

Issue

2

Start / End Page

220 / 223

Location

England

Related Subject Headings

  • Ventricular Remodeling
  • Protein Phosphatase 2C
  • Phosphoprotein Phosphatases
  • Humans
  • Heart Failure
  • Energy Metabolism
  • Cardiovascular System & Hematology
  • Animals
  • Amino Acids, Branched-Chain
  • 3201 Cardiovascular medicine and haematology
 

Citation

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Huang, Y., Zhou, M., Sun, H., & Wang, Y. (2011). Branched-chain amino acid metabolism in heart disease: an epiphenomenon or a real culprit? Cardiovasc Res, 90(2), 220–223. https://doi.org/10.1093/cvr/cvr070
Huang, Ying, Meiyi Zhou, Haipeng Sun, and Yibin Wang. “Branched-chain amino acid metabolism in heart disease: an epiphenomenon or a real culprit?Cardiovasc Res 90, no. 2 (May 1, 2011): 220–23. https://doi.org/10.1093/cvr/cvr070.
Huang Y, Zhou M, Sun H, Wang Y. Branched-chain amino acid metabolism in heart disease: an epiphenomenon or a real culprit? Cardiovasc Res. 2011 May 1;90(2):220–3.
Huang, Ying, et al. “Branched-chain amino acid metabolism in heart disease: an epiphenomenon or a real culprit?Cardiovasc Res, vol. 90, no. 2, May 2011, pp. 220–23. Pubmed, doi:10.1093/cvr/cvr070.
Huang Y, Zhou M, Sun H, Wang Y. Branched-chain amino acid metabolism in heart disease: an epiphenomenon or a real culprit? Cardiovasc Res. 2011 May 1;90(2):220–223.
Journal cover image

Published In

Cardiovasc Res

DOI

EISSN

1755-3245

Publication Date

May 1, 2011

Volume

90

Issue

2

Start / End Page

220 / 223

Location

England

Related Subject Headings

  • Ventricular Remodeling
  • Protein Phosphatase 2C
  • Phosphoprotein Phosphatases
  • Humans
  • Heart Failure
  • Energy Metabolism
  • Cardiovascular System & Hematology
  • Animals
  • Amino Acids, Branched-Chain
  • 3201 Cardiovascular medicine and haematology